ALWPs Improve Cognitive Function and Regulate Aβ Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer's Disease

Recently, we reported that ALWPs, which we developed by combining Liuwei Dihuang pills (LWPs) with antler, regulate the LPS-induced neuroinflammatory response and rescue LPS-induced short- and long-term memory impairment in wild-type (WT) mice. In the present study, we examined the effects of ALWPs...

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Published in:Frontiers in molecular neuroscience 2019-08, Vol.12, p.192-192
Main Authors: Nam, Youngpyo, Joo, Bitna, Lee, Ju-Young, Han, Kyung-Min, Ryu, Ka-Young, Koh, Young Ho, Kim, Jeongyeon, Koo, Ja Wook, We, Young-Man, Hoe, Hyang-Sook
Format: Article
Language:English
Subjects:
Alzheimer's disease
amyloid plaque
Amyloid precursor protein
Animal cognition
Brain research
Cognitive ability
Dendritic spines
Disease
Enzymes
Experiments
Extracellular signal-regulated kinase
Hippocampus
Inflammation
Kinases
Lipopolysaccharides
Long term memory
Medicine
Memory
Neuroscience
Oral administration
Pathology
Phosphorylation
Scopolamine
tau
Tau protein
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Summary:Recently, we reported that ALWPs, which we developed by combining Liuwei Dihuang pills (LWPs) with antler, regulate the LPS-induced neuroinflammatory response and rescue LPS-induced short- and long-term memory impairment in wild-type (WT) mice. In the present study, we examined the effects of ALWPs on Alzheimer's disease (AD) pathology and cognitive function in WT mice as well as 5x FAD mice (a mouse model of AD). We found that administration of ALWPs significantly reduced amyloid plaque levels in 5x FAD mice and significantly decreased amyloid β (Aβ) levels in amyloid precursor protein (APP)-overexpressing H4 cells. In addition, ALWPs administration significantly suppressed tau hyperphosphorylation in 5x FAD mice. Oral administration of ALWPs significantly improved long-term memory in scopolamine (SCO)-injected WT mice and 5x FAD mice by altering dendritic spine density. Importantly, ALWPs promoted spinogenesis in primary hippocampal neurons and WT mice and modulated the dendritic spine number in an extracellular signal-regulated kinase (ERK)-dependent manner. Taken together, our results suggest that ALWPs are a candidate therapeutic drug for AD that can modulate amyloid plaque load, tau phosphorylation, and synaptic/cognitive function.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2019.00192