Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms

A dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The propos...

Full description

Saved in:
Bibliographic Details
Published in:Química Nova 2010, Vol.33 (5), p.1150-1154
Main Authors: Dalmora, Sérgio Luiz, Nogueira, Daniele Rubert, Calegari, Guilherme Zanini, Bergamo, Ana Cláudia, Stamm, Fernanda Pavani
Format: Article
Language:English
Subjects:
CHEMISTRY, MULTIDISCIPLINARY
dissolution test
RP-LC
rupatadine
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c411t-539a5f60581717971309b22642ff47b6ac5a1e1b82377d41f02a01895f0c2d983
cites
container_end_page 1154
container_issue 5
container_start_page 1150
container_title Química Nova
container_volume 33
creator Dalmora, Sérgio Luiz
Nogueira, Daniele Rubert
Calegari, Guilherme Zanini
Bergamo, Ana Cláudia
Stamm, Fernanda Pavani
description A dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The proposed method was validated yielding acceptable results for the parameters evaluated, and was applied for the quality control analysis of rupatadine tablets, and to evaluate the formulation during an accelerated stability study. Moreover, quantitative analyses were also performed, to compare the applicability of the RP-LC and the LC-MS/MS methods.
doi_str_mv 10.1590/S0100-40422010000500028
format article
fullrecord <record><control><sourceid>scielo_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_101e17e725054c4689f5b11ca3902261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S0100_40422010000500028</scielo_id><doaj_id>oai_doaj_org_article_101e17e725054c4689f5b11ca3902261</doaj_id><sourcerecordid>S0100_40422010000500028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-539a5f60581717971309b22642ff47b6ac5a1e1b82377d41f02a01895f0c2d983</originalsourceid><addsrcrecordid>eNp1kc9uGyEQxlHVSHWTPEN4gU1nWFh2j1X6L1KkHtqe0ewCNtbabAGn8iP0rYvtKpeqhxGjYb7fDHyM3SHcoxrg3TdAgEaCFOKUAagaon_FVtjpvtHQydds9dL0hr3NeVs7dKvViv3-4J7dHJed2xdOe8ufaQ6WSoh7Hj0nbkPOcT6cC8Xlwn-FsuGpqlJ2tlk2lB2fw89DsHzapLijEteJls2x4mg-5pC5j4mnw0KFbNg7HiqJxtkVbmOmtTvd7_INu_I0Z3f797xmPz59_P7wpXn6-vnx4f1TM0nE0qh2IOU7UD1q1IPGFoZRiE4K76UeO5oUocOxF63WVqIHQYD9oDxMwg59e80eL1wbaWuWFHaUjiZSMOdCTGtDqYRpdgahkrTTQoGSk-z6wasRcaJ2gDoSK-v-wspTqL9otvGQ6qOzOZti_jGlCvRFMKWYc3L-ZQEEc7Lzv8o_1kuQ5g</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms</title><source>SciELO Brazil</source><creator>Dalmora, Sérgio Luiz ; Nogueira, Daniele Rubert ; Calegari, Guilherme Zanini ; Bergamo, Ana Cláudia ; Stamm, Fernanda Pavani</creator><creatorcontrib>Dalmora, Sérgio Luiz ; Nogueira, Daniele Rubert ; Calegari, Guilherme Zanini ; Bergamo, Ana Cláudia ; Stamm, Fernanda Pavani</creatorcontrib><description>A dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The proposed method was validated yielding acceptable results for the parameters evaluated, and was applied for the quality control analysis of rupatadine tablets, and to evaluate the formulation during an accelerated stability study. Moreover, quantitative analyses were also performed, to compare the applicability of the RP-LC and the LC-MS/MS methods.</description><identifier>ISSN: 0100-4042</identifier><identifier>ISSN: 1678-7064</identifier><identifier>EISSN: 1678-7064</identifier><identifier>DOI: 10.1590/S0100-40422010000500028</identifier><language>eng</language><publisher>Sociedade Brasileira de Química</publisher><subject>CHEMISTRY, MULTIDISCIPLINARY ; dissolution test ; RP-LC ; rupatadine</subject><ispartof>Química Nova, 2010, Vol.33 (5), p.1150-1154</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-539a5f60581717971309b22642ff47b6ac5a1e1b82377d41f02a01895f0c2d983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,24129,27901,27902</link.rule.ids></links><search><creatorcontrib>Dalmora, Sérgio Luiz</creatorcontrib><creatorcontrib>Nogueira, Daniele Rubert</creatorcontrib><creatorcontrib>Calegari, Guilherme Zanini</creatorcontrib><creatorcontrib>Bergamo, Ana Cláudia</creatorcontrib><creatorcontrib>Stamm, Fernanda Pavani</creatorcontrib><title>Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms</title><title>Química Nova</title><addtitle>Quím. Nova</addtitle><description>A dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The proposed method was validated yielding acceptable results for the parameters evaluated, and was applied for the quality control analysis of rupatadine tablets, and to evaluate the formulation during an accelerated stability study. Moreover, quantitative analyses were also performed, to compare the applicability of the RP-LC and the LC-MS/MS methods.</description><subject>CHEMISTRY, MULTIDISCIPLINARY</subject><subject>dissolution test</subject><subject>RP-LC</subject><subject>rupatadine</subject><issn>0100-4042</issn><issn>1678-7064</issn><issn>1678-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp1kc9uGyEQxlHVSHWTPEN4gU1nWFh2j1X6L1KkHtqe0ewCNtbabAGn8iP0rYvtKpeqhxGjYb7fDHyM3SHcoxrg3TdAgEaCFOKUAagaon_FVtjpvtHQydds9dL0hr3NeVs7dKvViv3-4J7dHJed2xdOe8ufaQ6WSoh7Hj0nbkPOcT6cC8Xlwn-FsuGpqlJ2tlk2lB2fw89DsHzapLijEteJls2x4mg-5pC5j4mnw0KFbNg7HiqJxtkVbmOmtTvd7_INu_I0Z3f797xmPz59_P7wpXn6-vnx4f1TM0nE0qh2IOU7UD1q1IPGFoZRiE4K76UeO5oUocOxF63WVqIHQYD9oDxMwg59e80eL1wbaWuWFHaUjiZSMOdCTGtDqYRpdgahkrTTQoGSk-z6wasRcaJ2gDoSK-v-wspTqL9otvGQ6qOzOZti_jGlCvRFMKWYc3L-ZQEEc7Lzv8o_1kuQ5g</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Dalmora, Sérgio Luiz</creator><creator>Nogueira, Daniele Rubert</creator><creator>Calegari, Guilherme Zanini</creator><creator>Bergamo, Ana Cláudia</creator><creator>Stamm, Fernanda Pavani</creator><general>Sociedade Brasileira de Química</general><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>2010</creationdate><title>Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms</title><author>Dalmora, Sérgio Luiz ; Nogueira, Daniele Rubert ; Calegari, Guilherme Zanini ; Bergamo, Ana Cláudia ; Stamm, Fernanda Pavani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-539a5f60581717971309b22642ff47b6ac5a1e1b82377d41f02a01895f0c2d983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>CHEMISTRY, MULTIDISCIPLINARY</topic><topic>dissolution test</topic><topic>RP-LC</topic><topic>rupatadine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dalmora, Sérgio Luiz</creatorcontrib><creatorcontrib>Nogueira, Daniele Rubert</creatorcontrib><creatorcontrib>Calegari, Guilherme Zanini</creatorcontrib><creatorcontrib>Bergamo, Ana Cláudia</creatorcontrib><creatorcontrib>Stamm, Fernanda Pavani</creatorcontrib><collection>CrossRef</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Química Nova</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dalmora, Sérgio Luiz</au><au>Nogueira, Daniele Rubert</au><au>Calegari, Guilherme Zanini</au><au>Bergamo, Ana Cláudia</au><au>Stamm, Fernanda Pavani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms</atitle><jtitle>Química Nova</jtitle><addtitle>Quím. Nova</addtitle><date>2010</date><risdate>2010</risdate><volume>33</volume><issue>5</issue><spage>1150</spage><epage>1154</epage><pages>1150-1154</pages><issn>0100-4042</issn><issn>1678-7064</issn><eissn>1678-7064</eissn><abstract>A dissolution test for in vitro evaluation of tablet dosage forms containing 10 mg of rupatadine was developed and validated by RP-LC. A discriminatory dissolution method was established using apparatus paddle at a stirring rate of 50 rpm with 900 mL of deaerated 0.01 M hydrochloric acid. The proposed method was validated yielding acceptable results for the parameters evaluated, and was applied for the quality control analysis of rupatadine tablets, and to evaluate the formulation during an accelerated stability study. Moreover, quantitative analyses were also performed, to compare the applicability of the RP-LC and the LC-MS/MS methods.</abstract><pub>Sociedade Brasileira de Química</pub><doi>10.1590/S0100-40422010000500028</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0100-4042
ispartof Química Nova, 2010, Vol.33 (5), p.1150-1154
issn 0100-4042
1678-7064
1678-7064
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_101e17e725054c4689f5b11ca3902261
source SciELO Brazil
subjects CHEMISTRY, MULTIDISCIPLINARY
dissolution test
RP-LC
rupatadine
title Development and validation of a dissolution test with reversed-phase liquid chromatography analysis for rupatadine in tablet dosage forms
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T11%3A05%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-scielo_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20and%20validation%20of%20a%20dissolution%20test%20with%20reversed-phase%20liquid%20chromatography%20analysis%20for%20rupatadine%20in%20tablet%20dosage%20forms&rft.jtitle=Qu%C3%ADmica%20Nova&rft.au=Dalmora,%20S%C3%A9rgio%20Luiz&rft.date=2010&rft.volume=33&rft.issue=5&rft.spage=1150&rft.epage=1154&rft.pages=1150-1154&rft.issn=0100-4042&rft.eissn=1678-7064&rft_id=info:doi/10.1590/S0100-40422010000500028&rft_dat=%3Cscielo_doaj_%3ES0100_40422010000500028%3C/scielo_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c411t-539a5f60581717971309b22642ff47b6ac5a1e1b82377d41f02a01895f0c2d983%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_scielo_id=S0100_40422010000500028&rfr_iscdi=true