Advances in Organic Fluorescent Probes for Intracellular Zn2+ Detection and Bioimaging

Zinc ions (Zn2+) play a key role in maintaining and regulating protein structures and functions. To better understand the intracellular Zn2+ homeostasis and signaling role, various fluorescent sensors have been developed that allow the monitoring of Zn2+ concentrations and bioimaging in live cells i...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-05, Vol.29 (11), p.2542
Main Author: Chen, Yi
Format: Article
Language:English
Subjects:
Design
detection
fluorescent probe
Homeostasis
imaging
intracellular Zn2
Ligands
Physiology
Prostate
Review
Signal transduction
Zinc
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Summary:Zinc ions (Zn2+) play a key role in maintaining and regulating protein structures and functions. To better understand the intracellular Zn2+ homeostasis and signaling role, various fluorescent sensors have been developed that allow the monitoring of Zn2+ concentrations and bioimaging in live cells in real time. This review highlights the recent development of organic fluorescent probes for the detection and imaging of intracellular Zn2+, including the design and construction of the probes, fluorescent response mechanisms, and their applications to intracellular Zn2+ detection and imaging on-site. Finally, the current challenges and prospects are discussed.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29112542