The Discordance of Gene Mutations between Circulating Tumor Cells and Primary/Metastatic Tumor

Circulating tumor cells (CTCs) are an important part in the field of “liquid biopsy.” However, major questions remain to be answered whether the mutations in the CTCs represent the mutations in primary tumor tissue and metastatic tumors. We compared the genetic mutations between CTCs and their match...

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Bibliographic Details
Published in:Molecular therapy. Oncolytics 2019-12, Vol.15, p.21-29
Main Authors: Wang, Qi, Zhao, Lanbo, Han, Lu, Tuo, Xiaoqian, Ma, Sijia, Wang, Yiran, Feng, Xue, Liang, Dongxin, Sun, Chao, Wang, Qing, Song, Qing, Li, Qiling
Format: Article
Language:English
Subjects:
Biopsy
Breast cancer
Cell adhesion & migration
clinical utility
Colorectal cancer
CTC
Discordance
Esophagus
Genes
heterogeneity
Lung cancer
Medical diagnosis
Melanoma
Metastases
Metastasis
Mutation
nutations
Patients
Prostate cancer
Researchers
Studies
Tumor cells
Tumors
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Summary:Circulating tumor cells (CTCs) are an important part in the field of “liquid biopsy.” However, major questions remain to be answered whether the mutations in the CTCs represent the mutations in primary tumor tissue and metastatic tumors. We compared the genetic mutations between CTCs and their matched tumors, and extracted data on the heterogeneity of the mutational status in CTCs and the change in mutations of CTCs before and during treatment. For mutations detected in single genes, we calculated the concordance of the mutations between the CTCs and primary tumor tissue. For mutations detected in multiple genes, we calculated the concordance of the mutations between the CTCs and primary/metastatic tumor tissue. The heterogeneity of the mutational status is clearly present in CTCs. For mutations detected in a single gene, the overall concordance of mutations is 53.05%. For mutations detected in multiple genes, the concordance of mutations is extremely different. The heterogeneity of the mutational status existed in single CTCs, and the mutational status of CTCs was discordant with that of tumor tissue.
ISSN:2372-7705
2372-7705
DOI:10.1016/j.omto.2019.08.006