Fabrication, Characterization, and Biological Evaluation of T. terrestris Incorporated Titanium-Doped ZnO/Cellulose Nanocomposite Films as a Therapeutic Hemostatic Scaffolds for Diabetic Wound Healing

• Published in: ACS omega 2024-04, Vol.9 (16), p.18327-18340
• Main Authors: Koshy, Jijo Thomas, Sangeetha, Dhanaraj, Bele, Yogesh, Rakshitha, Murugan
• Format: Article
• Language: English
• ISSN: 2470-1343; 2470-1343
• DOI: 10.1021/acsomega.4c00174

The advent of biobased materials exhibiting remarkable effectiveness and performance has ushered in a paradigm shift in the field of biomedical science. Polymers are often used in the medical sector, particularly in the regeneration of bones, tissues, and wounds. Fast wound healing and self-healing polymers created from sustainable surroundings are attractive alternatives to create demand for new pathways in polymer research. This study investigates the efficacy of a biowaste-derived polymer, which was extracted and supplemented with titanium-doped ZnO nanoparticles along with medication in the form of an extract to evaluate its effectiveness in promoting wound healing. The prepared materials were further characterized using X-ray diffraction (XRD), UV–visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), optical microscopy, atomic force microscopy (AFM), tensile, and its color parameters. In vitro studies on wound healing were also conducted. The results clearly showed that the produced substance possesses properties that are noteworthy for wound healing.