Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study

Copeptin is a novel biomarker that predicts mortality in lower respiratory tract infections and heart failure (HF), but the diagnostic value of copeptin in acute dyspnea and the prognostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is not clear....

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Bibliographic Details
Published in:Respiratory research 2017-11, Vol.18 (1), p.184-184, Article 184
Main Authors: Winther, Jacob A, Brynildsen, Jon, Høiseth, Arne Didrik, Strand, Heidi, Følling, Ivar, Christensen, Geir, Nygård, Ståle, Røsjø, Helge, Omland, Torbjørn
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Aged, 80 and over
Biomarkers
Cardiovascular disease
Care and treatment
Chronic obstructive lung disease
Chronic obstructive pulmonary disease
COPD
Copeptin
Coronary artery disease
Diagnosis
Diagnostic systems
Disease Progression
Dyspnea
Epidemiology
Female
Glycopeptides - blood
Heart attacks
Heart diseases
Heart failure
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - mortality
Hospitalization - trends
Humans
Lung diseases
Male
Medical prognosis
Middle Aged
Mortality
NT-proBNP
Obstructive lung disease
Patients
Peptides
Physiological aspects
Pituitary hormones
Prognosis
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - diagnosis
Pulmonary Disease, Chronic Obstructive - mortality
Respiration
Respiratory tract
Respiratory tract diseases
Risk analysis
Risk factors
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Summary:Copeptin is a novel biomarker that predicts mortality in lower respiratory tract infections and heart failure (HF), but the diagnostic value of copeptin in acute dyspnea and the prognostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is not clear. We determined copeptin and NT-proBNP concentrations at hospital admission in 314 patients with acute dyspnea who were categorized by diagnosis. Survival was registered after a median follow-up of 816 days, and the prognostic and diagnostic properties of copeptin and NT-proBNP were analyzed in acute HF (n = 143) and AECOPD (n = 84) separately. The median concentration of copeptin at admission was lower in AECOPD compared to acute HF (8.8 [5.2-19.7] vs. 22.2 [10.2-47.9]) pmol/L, p 
ISSN:1465-993X
1465-9921
1465-993X
1465-9921
DOI:10.1186/s12931-017-0665-z