Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity

Background Whether the sympathetic nervous system can directly alter central aortic stiffness remains controversial, mainly because of the difficulty in experimentally augmenting peripheral vasoconstrictor activity without changing blood pressure. Methods and Results To address this limitation, we u...

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Published in:Journal of the American Heart Association 2018-02, Vol.7 (3), p.n/a
Main Authors: Nardone, Massimo, Incognito, Anthony V., Millar, Philip J.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adult
Aorta - innervation
Arterial Pressure
arterial stiffness
autonomic nervous system
Baroreflex
blood pressure
Female
Heart Rate
Humans
Lower Body Negative Pressure
Male
muscle sympathetic nerve activity
Muscle, Skeletal - innervation
Original Research
Pulse Wave Analysis
Random Allocation
Sympathetic Nervous System - physiology
Vascular Stiffness
Young Adult
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creator Nardone, Massimo
Incognito, Anthony V.
Millar, Philip J.
description Background Whether the sympathetic nervous system can directly alter central aortic stiffness remains controversial, mainly because of the difficulty in experimentally augmenting peripheral vasoconstrictor activity without changing blood pressure. Methods and Results To address this limitation, we utilized low‐level cardiopulmonary baroreflex loading and unloading shown previously to alter sympathetic outflow without evoking parallel hemodynamic modulation. Blood pressure and carotid‐femoral aortic pulse wave velocity (cf‐PWV) were measured in 32 healthy participants (24±2 years; women: n=15) before and during 12‐minute applications of low‐level lower body negative pressure; −7 mm Hg) and lower body positive pressure; +7 mm Hg), applied in a random order. Fibular nerve microneurography was used to collect muscle sympathetic nerve activity (MSNA) in a subset (n=8) to confirm peripheral sympathetic responses. During lower body negative pressure, heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance were not statistically different (all P>0.05); MSNA burst frequency (+15%; P=0.007), total MSNA (+44%; P=0.006), and cf‐PWV (∆+0.3±0.2 m/s; P0.05), though blood pressure increased (P
doi_str_mv 10.1161/JAHA.117.007971
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Methods and Results To address this limitation, we utilized low‐level cardiopulmonary baroreflex loading and unloading shown previously to alter sympathetic outflow without evoking parallel hemodynamic modulation. Blood pressure and carotid‐femoral aortic pulse wave velocity (cf‐PWV) were measured in 32 healthy participants (24±2 years; women: n=15) before and during 12‐minute applications of low‐level lower body negative pressure; −7 mm Hg) and lower body positive pressure; +7 mm Hg), applied in a random order. Fibular nerve microneurography was used to collect muscle sympathetic nerve activity (MSNA) in a subset (n=8) to confirm peripheral sympathetic responses. During lower body negative pressure, heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance were not statistically different (all P&gt;0.05); MSNA burst frequency (+15%; P=0.007), total MSNA (+44%; P=0.006), and cf‐PWV (∆+0.3±0.2 m/s; P&lt;0.001) increased. In total, 28 (88%) of participants observed an increase in cf‐PWV greater than the baseline typical error of measurement. During lower body positive pressure, heart rate, stroke volume, cardiac output, and total peripheral resistance were not statistically different (all P&gt;0.05), though blood pressure increased (P&lt;0.05) and pulse pressure decreased (P=0.01); MSNA burst frequency (−4%; P=0.37), total MSNA (−7%; P=0.89), and cf‐PWV (∆0.0±0.2 m/s; P=0.68) were not statistically different. Conclusions These findings provide evidence that acute elevations in peripheral sympathetic activity can increase central aortic PWV in young participants independent of a change in distending or pulsatile blood pressure or heart rate.</description><identifier>ISSN: 2047-9980</identifier><identifier>EISSN: 2047-9980</identifier><identifier>DOI: 10.1161/JAHA.117.007971</identifier><identifier>PMID: 29378730</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>Adaptation, Physiological ; Adult ; Aorta - innervation ; Arterial Pressure ; arterial stiffness ; autonomic nervous system ; Baroreflex ; blood pressure ; Female ; Heart Rate ; Humans ; Lower Body Negative Pressure ; Male ; muscle sympathetic nerve activity ; Muscle, Skeletal - innervation ; Original Research ; Pulse Wave Analysis ; Random Allocation ; Sympathetic Nervous System - physiology ; Vascular Stiffness ; Young Adult</subject><ispartof>Journal of the American Heart Association, 2018-02, Vol.7 (3), p.n/a</ispartof><rights>2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5716-e10b4898c2a90e3e8285259eabc24a89e81df61b68f455273c16496dce54bfc53</citedby><cites>FETCH-LOGICAL-c5716-e10b4898c2a90e3e8285259eabc24a89e81df61b68f455273c16496dce54bfc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850264/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850264/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,27924,27925,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29378730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nardone, Massimo</creatorcontrib><creatorcontrib>Incognito, Anthony V.</creatorcontrib><creatorcontrib>Millar, Philip J.</creatorcontrib><title>Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity</title><title>Journal of the American Heart Association</title><addtitle>J Am Heart Assoc</addtitle><description>Background Whether the sympathetic nervous system can directly alter central aortic stiffness remains controversial, mainly because of the difficulty in experimentally augmenting peripheral vasoconstrictor activity without changing blood pressure. Methods and Results To address this limitation, we utilized low‐level cardiopulmonary baroreflex loading and unloading shown previously to alter sympathetic outflow without evoking parallel hemodynamic modulation. Blood pressure and carotid‐femoral aortic pulse wave velocity (cf‐PWV) were measured in 32 healthy participants (24±2 years; women: n=15) before and during 12‐minute applications of low‐level lower body negative pressure; −7 mm Hg) and lower body positive pressure; +7 mm Hg), applied in a random order. Fibular nerve microneurography was used to collect muscle sympathetic nerve activity (MSNA) in a subset (n=8) to confirm peripheral sympathetic responses. During lower body negative pressure, heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance were not statistically different (all P&gt;0.05); MSNA burst frequency (+15%; P=0.007), total MSNA (+44%; P=0.006), and cf‐PWV (∆+0.3±0.2 m/s; P&lt;0.001) increased. In total, 28 (88%) of participants observed an increase in cf‐PWV greater than the baseline typical error of measurement. During lower body positive pressure, heart rate, stroke volume, cardiac output, and total peripheral resistance were not statistically different (all P&gt;0.05), though blood pressure increased (P&lt;0.05) and pulse pressure decreased (P=0.01); MSNA burst frequency (−4%; P=0.37), total MSNA (−7%; P=0.89), and cf‐PWV (∆0.0±0.2 m/s; P=0.68) were not statistically different. Conclusions These findings provide evidence that acute elevations in peripheral sympathetic activity can increase central aortic PWV in young participants independent of a change in distending or pulsatile blood pressure or heart rate.</description><subject>Adaptation, Physiological</subject><subject>Adult</subject><subject>Aorta - innervation</subject><subject>Arterial Pressure</subject><subject>arterial stiffness</subject><subject>autonomic nervous system</subject><subject>Baroreflex</subject><subject>blood pressure</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Lower Body Negative Pressure</subject><subject>Male</subject><subject>muscle sympathetic nerve activity</subject><subject>Muscle, Skeletal - innervation</subject><subject>Original Research</subject><subject>Pulse Wave Analysis</subject><subject>Random Allocation</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vascular Stiffness</subject><subject>Young Adult</subject><issn>2047-9980</issn><issn>2047-9980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>DOA</sourceid><recordid>eNqFkU1P3DAQhqOqVUGUc29Vjr0seOz461JptaJlK6oi0Q_1ZDnOGIKy8dZOFu2Nn9Df2F9SLwEEp_pgj2deP-PRWxRvgRwBCDj-PD-d50geESK1hBfFPiWVnGmtyMsn8V5xmNI1yUtQybh-XexRzaSSjOwXv042bYO9w9KHWJ5HTGmM-Pf2z7JvcI1564fyYrta2-EKh9aVX0IzdnZoQ18GXy5yOdquPB-7hOVPu8HyB3bBtcP2TfHK25w9vD8Piu8fT74tTmdnXz8tF_OzmeMSxAyB1JXSylGrCTJUVHHKNdra0coqjQoaL6AWylec5wEciEqLxiGvau84OyiWE7cJ9tqsY7uycWuCbc1dIsRLY2P-eYcGCGtELZVTDCrRCMu8lTVI4RlI511mfZhY67FeYe5xN90z6PNK316Zy7AxXHFCRZUB7-8BMfweMQ1m1SaHXWd7DGMyoDUjABRYlh5PUhdDShH9YxsgZuev2fmbI2kmf_OLd09_96h_cDML-CS4aTvc_o-3uzOqqWD_AH-PsfE</recordid><startdate>20180206</startdate><enddate>20180206</enddate><creator>Nardone, Massimo</creator><creator>Incognito, Anthony V.</creator><creator>Millar, Philip J.</creator><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20180206</creationdate><title>Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity</title><author>Nardone, Massimo ; Incognito, Anthony V. ; Millar, Philip J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5716-e10b4898c2a90e3e8285259eabc24a89e81df61b68f455273c16496dce54bfc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adaptation, Physiological</topic><topic>Adult</topic><topic>Aorta - innervation</topic><topic>Arterial Pressure</topic><topic>arterial stiffness</topic><topic>autonomic nervous system</topic><topic>Baroreflex</topic><topic>blood pressure</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Lower Body Negative Pressure</topic><topic>Male</topic><topic>muscle sympathetic nerve activity</topic><topic>Muscle, Skeletal - innervation</topic><topic>Original Research</topic><topic>Pulse Wave Analysis</topic><topic>Random Allocation</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vascular Stiffness</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nardone, Massimo</creatorcontrib><creatorcontrib>Incognito, Anthony V.</creatorcontrib><creatorcontrib>Millar, Philip J.</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of the American Heart Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nardone, Massimo</au><au>Incognito, Anthony V.</au><au>Millar, Philip J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity</atitle><jtitle>Journal of the American Heart Association</jtitle><addtitle>J Am Heart Assoc</addtitle><date>2018-02-06</date><risdate>2018</risdate><volume>7</volume><issue>3</issue><epage>n/a</epage><issn>2047-9980</issn><eissn>2047-9980</eissn><abstract>Background Whether the sympathetic nervous system can directly alter central aortic stiffness remains controversial, mainly because of the difficulty in experimentally augmenting peripheral vasoconstrictor activity without changing blood pressure. Methods and Results To address this limitation, we utilized low‐level cardiopulmonary baroreflex loading and unloading shown previously to alter sympathetic outflow without evoking parallel hemodynamic modulation. Blood pressure and carotid‐femoral aortic pulse wave velocity (cf‐PWV) were measured in 32 healthy participants (24±2 years; women: n=15) before and during 12‐minute applications of low‐level lower body negative pressure; −7 mm Hg) and lower body positive pressure; +7 mm Hg), applied in a random order. Fibular nerve microneurography was used to collect muscle sympathetic nerve activity (MSNA) in a subset (n=8) to confirm peripheral sympathetic responses. During lower body negative pressure, heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance were not statistically different (all P&gt;0.05); MSNA burst frequency (+15%; P=0.007), total MSNA (+44%; P=0.006), and cf‐PWV (∆+0.3±0.2 m/s; P&lt;0.001) increased. In total, 28 (88%) of participants observed an increase in cf‐PWV greater than the baseline typical error of measurement. During lower body positive pressure, heart rate, stroke volume, cardiac output, and total peripheral resistance were not statistically different (all P&gt;0.05), though blood pressure increased (P&lt;0.05) and pulse pressure decreased (P=0.01); MSNA burst frequency (−4%; P=0.37), total MSNA (−7%; P=0.89), and cf‐PWV (∆0.0±0.2 m/s; P=0.68) were not statistically different. Conclusions These findings provide evidence that acute elevations in peripheral sympathetic activity can increase central aortic PWV in young participants independent of a change in distending or pulsatile blood pressure or heart rate.</abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>29378730</pmid><doi>10.1161/JAHA.117.007971</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects Adaptation, Physiological
Adult
Aorta - innervation
Arterial Pressure
arterial stiffness
autonomic nervous system
Baroreflex
blood pressure
Female
Heart Rate
Humans
Lower Body Negative Pressure
Male
muscle sympathetic nerve activity
Muscle, Skeletal - innervation
Original Research
Pulse Wave Analysis
Random Allocation
Sympathetic Nervous System - physiology
Vascular Stiffness
Young Adult
title Evidence for Pressure‐Independent Sympathetic Modulation of Central Pulse Wave Velocity
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