Synthetic Haemostatic Sealants: Effectiveness, Safety, and In Vivo Applications

Rapid haemostasis during surgery is essential when one wants to reduce the duration of operations, reduce the need for transfusions, and above all when one wants to achieve better patient management. The use of haemostatic agents, sealants, and adhesives improves the haemostatic process by offering...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2024-02, Vol.17 (3), p.288
Main Authors: Curcio, Federica, Perri, Paolo, Piro, Paolo, Galassi, Stefania, Sole, Roberta, Trombino, Sonia, Cassano, Roberta
Format: Article
Language:English
Subjects:
Adhesion
Adhesives
Antibiotics
Anticoagulants
Antihypertensives
Biocompatibility
Blood clots
Bond strength
Chemical bonds
cyanoacrylate-based glues
Electrocardiography
Fistula
Hemodialysis
International organizations
Medical equipment
Performance evaluation
Polymerization
polysaccharide hydrogel-microsphere powder
Pseudoaneurysm
Shear strength
Tensile strength
tissue adhesive
Toxicity
vascular application
Veins & arteries
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Summary:Rapid haemostasis during surgery is essential when one wants to reduce the duration of operations, reduce the need for transfusions, and above all when one wants to achieve better patient management. The use of haemostatic agents, sealants, and adhesives improves the haemostatic process by offering several advantages, especially in vascular surgery. These agents vary widely in their mechanism of action, composition, ease of application, adhesion to wet or dry tissue, immunogenicity, and cost. The most used are cyanoacrylate-based glues (Glubran 2) or polysaccharide hydrogel-microsphere powder (Arista AH). This work is based on a retrospective study carried out on a sample of patients with different vascular diseases (FAV, pseudoaneurysm, and PICC application) in which two different haemostatic sealants were used. The aim was to assess the safety, the advantages, and the ability of both sealants to activate the haemostatic process at the affected site, also in relation to their chemical-physical characteristics. The obtained results showed that the application of Glubran 2 and Arista AH as surgical wound closure systems is effective and safe, as the success achieved was ≥94% on anastomoses of FAV, 100% on stabilization of PICC catheters, and ≤95% on pseudoaneurysms.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph17030288