Long-term time trends in reactivated herpes simplex infections and treatment in Sweden

Our aim was to describe the annual prevalence of herpes simplex virus (HSV) reactivation in relation to solar ultraviolet (UV) radiation and antiviral drug use in the Swedish adult population. The study comprised 2879 anti-HSV-1 immunoglobulin (Ig) G positive subjects from five different cohorts who...

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Bibliographic Details
Published in:BMC infectious diseases 2022-06, Vol.22 (1), p.547-547, Article 547
Main Authors: Lopatko Lindman, Karin, Lockman-Lundgren, Judith, Weidung, Bodil, Olsson, Jan, Elgh, Fredrik, Lövheim, Hugo
Format: Article
Language:English
Subjects:
Age
Alzheimer's disease
Antibodies
Antiviral agents
Apolipoprotein E
Apolipoprotein E4
Cohort analysis
Cohort study
Drug dosages
Drug therapy
Drugs
Enzyme-linked immunosorbent assay
Epidemiology
Herpes simplex
Herpes viruses
Immunoglobulin M
Infections
Infectious diseases
Pharmaceutical industry
Pharmacy
Population
Population studies
Prescription drugs
Risk factors
Seasonal variations
Serology
Seroprevalence
Statistics
Trends
Ultraviolet radiation
Viruses
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Summary:Our aim was to describe the annual prevalence of herpes simplex virus (HSV) reactivation in relation to solar ultraviolet (UV) radiation and antiviral drug use in the Swedish adult population. The study comprised 2879 anti-HSV-1 immunoglobulin (Ig) G positive subjects from five different cohorts who had donated serum from 1988 to 2010. The sera were analyzed for anti-HSV IgM using enzyme-linked immunosorbent assay. Associations between the presence of anti-HSV IgM antibodies, the apolipoprotein E ε4 allele and the serum sampling year were assessed by logistic regression. Seasonality of anti-HSV IgM was evaluated in a UV radiation model. Data of antiviral drugs for the entire Swedish population were compiled from two different nationwide databases: the Swedish Prescribed Drug Register and the Swedish Association of the Pharmaceutical Industry. Cross-sectional and longitudinal analyses indicated that the prevalence of anti-HSV IgM antibodies declined between 1988 and 2010 (odds ratio [OR] = 0.912, p 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-022-07525-w