Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale

A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC50 values of 11-45 μg/mL.

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Bibliographic Details
Published in:Marine drugs 2005-06, Vol.3 (2), p.29-35
Main Authors: Tsukamoto, Sachiko, Koimaru, Keiichirou, Ohta, Tomihisa
Format: Article
Language:English
Subjects:
Marine
marine sponge
Mycale
mycalolide A
proteasome inhibitor
secomycalolide A
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Description
Summary:A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC50 values of 11-45 μg/mL.
ISSN:1660-3397
1660-3397
DOI:10.3390/md302029