Measuring the effects of exercise in neuromuscular disorders: a systematic review and meta-analyses

The benefit and safety of exercise training for patients with neuromuscular disorders (NMDs) has long been a contentious topic. This is, in part, due to recognised challenges associated with rare diseases including small and heterogenous patient populations. We performed a systematic review and meta...

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Bibliographic Details
Published in:Wellcome open research 2020, Vol.5, p.84-84
Main Authors: Stefanetti, Renae J, Blain, Alasdair, Jimenez-Moreno, Cecilia, Errington, Linda, Ng, Yi Shiau, McFarland, Robert, Turnbull, Doug M, Newman, Jane, Gorman, Gráinne S
Format: Article
Language:English
Subjects:
Activities of daily living
Bias
Clinical medicine
Exercise
Fitness training programs
Intervention
Meta-analysis
Peer review
Physical fitness
Quality of life
Rare diseases
Studies
Systematic Review
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Summary:The benefit and safety of exercise training for patients with neuromuscular disorders (NMDs) has long been a contentious topic. This is, in part, due to recognised challenges associated with rare diseases including small and heterogenous patient populations. We performed a systematic review and meta-analyses to evaluate the effectiveness and safety of interventional exercise and establish minimal clinically important differences (MCID) in outcomes to facilitate clinical interpretation. We searched six databases from inception to Mar 2018. Aerobic, strength, and combined (aerobic and strength) intervention were eligible. Meta-analyses compared outcomes at baseline with those after at least six weeks (before-after exercise within individuals). A further meta-analysis compared outcomes before-after exercise between groups (exercise training versus usual care). Disease heterogeneity was explored using a random effect model. This study was registered (PROSPERO, CRD42018102183). An interactive database was developed to facilitate full interrogations of data. We identified 130 articles describing 1,805 participants with 35 different forms of NMD. Of these studies, 76 were suitable for meta-analyses. Within group and between group meta-analyses detected an increase in peak aerobic capacity (p=0·04), and peak power (p=0·01). Six-minute walk test (p=0·04), sit-to-stand (STS) (repetitions) (p=0·03), STS (seconds) (p=0·04), rise from supine (p=0·008), SF-36 (p=0·0003), fatigue severity (p=
ISSN:2398-502X
2398-502X
DOI:10.12688/wellcomeopenres.15825.1