Association Between Polymorphisms in the 5' Region of the GALR1 Gene and Schizophrenia in the Northern Chinese Han Population: A Case-Control Study

Epidemiological studies have shown that genetic factors are among the causes of schizophrenia. Galanin receptor 1 is an inhibitory receptor of galanin that is widely distributed in the central nervous system. This study mainly explored the relationship between polymorphisms of the 5' region of...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2020-01, Vol.16, p.1519-1532
Main Authors: Li, Ya, Gao, Meng, Zeng, Kuo, Xing, Jia-Xin, Xu, Feng-Ling, Xuan, Jin-Feng, Xia, Xi, Liu, Yong-Ping, Yao, Jun, Wang, Bao-Jie
Format: Article
Language:English
Subjects:
Addictions
Age
Alleles
Alzheimer's disease
Analysis
Blood & organ donations
Central nervous system
Deoxyribonucleic acid
DNA
Dopamine
Epidemiology
Ethnicity
Females
Galanin
galanin receptor 1
Gene expression
Genes
Genetic aspects
Genetic factors
genetic polymorphism
Genetic research
Genotype & phenotype
Haplotypes
Males
Mental depression
Mental disorders
Mental health care
Nervous system
Neuropeptides
northern chinese han population
Original Research
Physiology
Polymerase chain reaction
Polymorphism
Population
Population studies
Schizophrenia
Sex differences
Single nucleotide polymorphisms
Single-nucleotide polymorphism
single-nucleotide variant
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Summary:Epidemiological studies have shown that genetic factors are among the causes of schizophrenia. Galanin receptor 1 is an inhibitory receptor of galanin that is widely distributed in the central nervous system. This study mainly explored the relationship between polymorphisms of the 5' region of the gene and schizophrenia in the northern Chinese Han population. A 1545 bp fragment of the 5' regulatory region of the gene was amplified and sequenced in 289 schizophrenia patients and 347 healthy controls. Among the haplotypes composed of the 16 detected SNPs, the haplotype H3 was identified as conferring a risk of schizophrenia ( =0.011, OR=1.430, 95% CI=1.084-1.886). In addition, the haplotypes H4 and H7 were both protective against schizophrenia ( =0.024, OR=0.526, 95% CI=0.298-0.927; =0.037, OR=0.197, 95% CI=0.044-0.885, respectively). In the subgroup analysis by sex, it was found that seven SNP alleles (rs72978691, rs11662010, rs11151014, rs11151015, rs13306374, rs5373, rs13306375) conferred a risk of schizophrenia in females (
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S256644