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Association Between Polymorphisms in the 5' Region of the GALR1 Gene and Schizophrenia in the Northern Chinese Han Population: A Case-Control Study
Epidemiological studies have shown that genetic factors are among the causes of schizophrenia. Galanin receptor 1 is an inhibitory receptor of galanin that is widely distributed in the central nervous system. This study mainly explored the relationship between polymorphisms of the 5' region of...
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| Published in: | Neuropsychiatric disease and treatment 2020-01, Vol.16, p.1519-1532 |
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| container_title | Neuropsychiatric disease and treatment |
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| creator | Li, Ya Gao, Meng Zeng, Kuo Xing, Jia-Xin Xu, Feng-Ling Xuan, Jin-Feng Xia, Xi Liu, Yong-Ping Yao, Jun Wang, Bao-Jie |
| description | Epidemiological studies have shown that genetic factors are among the causes of schizophrenia. Galanin receptor 1 is an inhibitory receptor of galanin that is widely distributed in the central nervous system. This study mainly explored the relationship between polymorphisms of the 5' region of the
gene and schizophrenia in the northern Chinese Han population.
A 1545 bp fragment of the 5' regulatory region of the
gene was amplified and sequenced in 289 schizophrenia patients and 347 healthy controls.
Among the haplotypes composed of the 16 detected SNPs, the haplotype H3 was identified as conferring a risk of schizophrenia (
=0.011, OR=1.430, 95% CI=1.084-1.886). In addition, the haplotypes H4 and H7 were both protective against schizophrenia (
=0.024, OR=0.526, 95% CI=0.298-0.927;
=0.037, OR=0.197, 95% CI=0.044-0.885, respectively). In the subgroup analysis by sex, it was found that seven SNP alleles (rs72978691, rs11662010, rs11151014, rs11151015, rs13306374, rs5373, rs13306375) conferred a risk of schizophrenia in females ( |
| doi_str_mv | 10.2147/NDT.S256644 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_1077b0c8f9c945b4bfc1a9af6d568deb</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A631814173</galeid><doaj_id>oai_doaj_org_article_1077b0c8f9c945b4bfc1a9af6d568deb</doaj_id><sourcerecordid>A631814173</sourcerecordid><originalsourceid>FETCH-LOGICAL-c573t-61cd22a727a18ed7d496af5026a53d12f3f507981f5a06503dd80b843da60ea23</originalsourceid><addsrcrecordid>eNptkt9v0zAQgCMEYmPwxDuyhARIqMU_EjvdA1Ip0E2qBlrHs-Xal8ZVahc7AZV_g38Yp-3GilAeHJ-_-6w7X5Y9J3hISS7eXX28Gc5pwXmeP8hOCRHlgGJKHu7--YAzWp5kT2JcYczEqCwfZyeMcswFzk-z3-MYvbaqtd6hD9D-BHDoq2-2ax82tY3riKxDbQ2oeI2uYdljvtoFpuPZNUFTcICUM2iua_vLb-oAzqrbpCsf0hIcmtTWQQR0oXr9pmt2N56jMZqoCIOJd23wDZq3ndk-zR5Vqonw7LCeZd8-f7qZXAxmX6aXk_FsoAvB2gEn2lCqBBWKlGCEyUdcVQWmXBXMEFqxtEkFk6pQmBeYGVPiRZkzozgGRdlZdrn3Gq9WchPsWoWt9MrKXcCHpVShtboBSbAQC6zLaqRHebHIF5UmaqQqbgpeGlgk1_u9a9Mt1mA0pHpUcyQ9PnG2lkv_QwqGeS5wErw5CIL_3kFs5dpGDU2jHPguSpqTUU5wUbCEvvwHXfkuuNSqnsoJIRTzv9RSpQKsq3y6V_dSOeaMlAkUvWv4Hyp9BtZWeweVTfGjhFf3EmpQTVtH33T9c8Zj8O0e1MHHGKC6awbBsh9cmQZXHgY30S_u9--OvZ1U9gdn0eYy</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2414111206</pqid></control><display><type>article</type><title>Association Between Polymorphisms in the 5' Region of the GALR1 Gene and Schizophrenia in the Northern Chinese Han Population: A Case-Control Study</title><source>Publicly Available Content Database</source><source>Taylor & Francis Open Access Journals</source><source>PubMed Central</source><creator>Li, Ya ; Gao, Meng ; Zeng, Kuo ; Xing, Jia-Xin ; Xu, Feng-Ling ; Xuan, Jin-Feng ; Xia, Xi ; Liu, Yong-Ping ; Yao, Jun ; Wang, Bao-Jie</creator><creatorcontrib>Li, Ya ; Gao, Meng ; Zeng, Kuo ; Xing, Jia-Xin ; Xu, Feng-Ling ; Xuan, Jin-Feng ; Xia, Xi ; Liu, Yong-Ping ; Yao, Jun ; Wang, Bao-Jie</creatorcontrib><description>Epidemiological studies have shown that genetic factors are among the causes of schizophrenia. Galanin receptor 1 is an inhibitory receptor of galanin that is widely distributed in the central nervous system. This study mainly explored the relationship between polymorphisms of the 5' region of the
gene and schizophrenia in the northern Chinese Han population.
A 1545 bp fragment of the 5' regulatory region of the
gene was amplified and sequenced in 289 schizophrenia patients and 347 healthy controls.
Among the haplotypes composed of the 16 detected SNPs, the haplotype H3 was identified as conferring a risk of schizophrenia (
=0.011, OR=1.430, 95% CI=1.084-1.886). In addition, the haplotypes H4 and H7 were both protective against schizophrenia (
=0.024, OR=0.526, 95% CI=0.298-0.927;
=0.037, OR=0.197, 95% CI=0.044-0.885, respectively). In the subgroup analysis by sex, it was found that seven SNP alleles (rs72978691, rs11662010, rs11151014, rs11151015, rs13306374, rs5373, rs13306375) conferred a risk of schizophrenia in females (
<0.05), while allele G of rs7242919 (
=0.007) was protective against schizophrenia in females. Moreover, the rs72978691 AA+AC genotype (
=0.006, OR=1.874, 95% CI=1.196-2.937, power=0.780), rs7242919 CC+CG genotype (
=0.002, OR=2.027, 95% CI=1.292-3.180, power=0.861), rs11151014 GG+GT genotype (
=0.008, OR=1.834, 95% CI=1.168-2.879, power=0.735), rs11151015 GG+AG genotype (
=0.002, OR=2.013, 95% CI =1.291-3.137, power=0.843), rs13306374 CC+AC genotype (
=0.006, OR=1.881, 95% CI=1.198-2.953, power=0.788), and rs13306375 GG+AG genotype (
=0.006, OR=1.868, 95% CI=1.194-2.921, power=0.770) increased the risk of schizophrenia in females. The haplotype FH2 consisting of rs72978691, rs11662010, rs7242919, rs11151014, rs11151015, rs13306374, rs5373, and rs13306375 may also be associated with the risk of schizophrenia in females (
=0.024).
This study identified an association between polymorphisms in the 5' region of the
gene and schizophrenia, especially in females.</description><identifier>ISSN: 1176-6328</identifier><identifier>ISSN: 1178-2021</identifier><identifier>EISSN: 1178-2021</identifier><identifier>DOI: 10.2147/NDT.S256644</identifier><identifier>PMID: 32606704</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Addictions ; Age ; Alleles ; Alzheimer's disease ; Analysis ; Blood & organ donations ; Central nervous system ; Deoxyribonucleic acid ; DNA ; Dopamine ; Epidemiology ; Ethnicity ; Females ; Galanin ; galanin receptor 1 ; Gene expression ; Genes ; Genetic aspects ; Genetic factors ; genetic polymorphism ; Genetic research ; Genotype & phenotype ; Haplotypes ; Males ; Mental depression ; Mental disorders ; Mental health care ; Nervous system ; Neuropeptides ; northern chinese han population ; Original Research ; Physiology ; Polymerase chain reaction ; Polymorphism ; Population ; Population studies ; Schizophrenia ; Sex differences ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; single-nucleotide variant</subject><ispartof>Neuropsychiatric disease and treatment, 2020-01, Vol.16, p.1519-1532</ispartof><rights>2020 Li et al.</rights><rights>COPYRIGHT 2020 Dove Medical Press Limited</rights><rights>2020. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Li et al. 2020 Li et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-61cd22a727a18ed7d496af5026a53d12f3f507981f5a06503dd80b843da60ea23</citedby><cites>FETCH-LOGICAL-c573t-61cd22a727a18ed7d496af5026a53d12f3f507981f5a06503dd80b843da60ea23</cites><orcidid>0000-0003-0781-5694</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2414111206/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2414111206?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32606704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ya</creatorcontrib><creatorcontrib>Gao, Meng</creatorcontrib><creatorcontrib>Zeng, Kuo</creatorcontrib><creatorcontrib>Xing, Jia-Xin</creatorcontrib><creatorcontrib>Xu, Feng-Ling</creatorcontrib><creatorcontrib>Xuan, Jin-Feng</creatorcontrib><creatorcontrib>Xia, Xi</creatorcontrib><creatorcontrib>Liu, Yong-Ping</creatorcontrib><creatorcontrib>Yao, Jun</creatorcontrib><creatorcontrib>Wang, Bao-Jie</creatorcontrib><title>Association Between Polymorphisms in the 5' Region of the GALR1 Gene and Schizophrenia in the Northern Chinese Han Population: A Case-Control Study</title><title>Neuropsychiatric disease and treatment</title><addtitle>Neuropsychiatr Dis Treat</addtitle><description>Epidemiological studies have shown that genetic factors are among the causes of schizophrenia. Galanin receptor 1 is an inhibitory receptor of galanin that is widely distributed in the central nervous system. This study mainly explored the relationship between polymorphisms of the 5' region of the
gene and schizophrenia in the northern Chinese Han population.
A 1545 bp fragment of the 5' regulatory region of the
gene was amplified and sequenced in 289 schizophrenia patients and 347 healthy controls.
Among the haplotypes composed of the 16 detected SNPs, the haplotype H3 was identified as conferring a risk of schizophrenia (
=0.011, OR=1.430, 95% CI=1.084-1.886). In addition, the haplotypes H4 and H7 were both protective against schizophrenia (
=0.024, OR=0.526, 95% CI=0.298-0.927;
=0.037, OR=0.197, 95% CI=0.044-0.885, respectively). In the subgroup analysis by sex, it was found that seven SNP alleles (rs72978691, rs11662010, rs11151014, rs11151015, rs13306374, rs5373, rs13306375) conferred a risk of schizophrenia in females (
<0.05), while allele G of rs7242919 (
=0.007) was protective against schizophrenia in females. Moreover, the rs72978691 AA+AC genotype (
=0.006, OR=1.874, 95% CI=1.196-2.937, power=0.780), rs7242919 CC+CG genotype (
=0.002, OR=2.027, 95% CI=1.292-3.180, power=0.861), rs11151014 GG+GT genotype (
=0.008, OR=1.834, 95% CI=1.168-2.879, power=0.735), rs11151015 GG+AG genotype (
=0.002, OR=2.013, 95% CI =1.291-3.137, power=0.843), rs13306374 CC+AC genotype (
=0.006, OR=1.881, 95% CI=1.198-2.953, power=0.788), and rs13306375 GG+AG genotype (
=0.006, OR=1.868, 95% CI=1.194-2.921, power=0.770) increased the risk of schizophrenia in females. The haplotype FH2 consisting of rs72978691, rs11662010, rs7242919, rs11151014, rs11151015, rs13306374, rs5373, and rs13306375 may also be associated with the risk of schizophrenia in females (
=0.024).
This study identified an association between polymorphisms in the 5' region of the
gene and schizophrenia, especially in females.</description><subject>Addictions</subject><subject>Age</subject><subject>Alleles</subject><subject>Alzheimer's disease</subject><subject>Analysis</subject><subject>Blood & organ donations</subject><subject>Central nervous system</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Dopamine</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Females</subject><subject>Galanin</subject><subject>galanin receptor 1</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic factors</subject><subject>genetic polymorphism</subject><subject>Genetic research</subject><subject>Genotype & phenotype</subject><subject>Haplotypes</subject><subject>Males</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental health care</subject><subject>Nervous system</subject><subject>Neuropeptides</subject><subject>northern chinese han population</subject><subject>Original Research</subject><subject>Physiology</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Population</subject><subject>Population studies</subject><subject>Schizophrenia</subject><subject>Sex differences</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>single-nucleotide variant</subject><issn>1176-6328</issn><issn>1178-2021</issn><issn>1178-2021</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkt9v0zAQgCMEYmPwxDuyhARIqMU_EjvdA1Ip0E2qBlrHs-Xal8ZVahc7AZV_g38Yp-3GilAeHJ-_-6w7X5Y9J3hISS7eXX28Gc5pwXmeP8hOCRHlgGJKHu7--YAzWp5kT2JcYczEqCwfZyeMcswFzk-z3-MYvbaqtd6hD9D-BHDoq2-2ax82tY3riKxDbQ2oeI2uYdljvtoFpuPZNUFTcICUM2iua_vLb-oAzqrbpCsf0hIcmtTWQQR0oXr9pmt2N56jMZqoCIOJd23wDZq3ndk-zR5Vqonw7LCeZd8-f7qZXAxmX6aXk_FsoAvB2gEn2lCqBBWKlGCEyUdcVQWmXBXMEFqxtEkFk6pQmBeYGVPiRZkzozgGRdlZdrn3Gq9WchPsWoWt9MrKXcCHpVShtboBSbAQC6zLaqRHebHIF5UmaqQqbgpeGlgk1_u9a9Mt1mA0pHpUcyQ9PnG2lkv_QwqGeS5wErw5CIL_3kFs5dpGDU2jHPguSpqTUU5wUbCEvvwHXfkuuNSqnsoJIRTzv9RSpQKsq3y6V_dSOeaMlAkUvWv4Hyp9BtZWeweVTfGjhFf3EmpQTVtH33T9c8Zj8O0e1MHHGKC6awbBsh9cmQZXHgY30S_u9--OvZ1U9gdn0eYy</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Li, Ya</creator><creator>Gao, Meng</creator><creator>Zeng, Kuo</creator><creator>Xing, Jia-Xin</creator><creator>Xu, Feng-Ling</creator><creator>Xuan, Jin-Feng</creator><creator>Xia, Xi</creator><creator>Liu, Yong-Ping</creator><creator>Yao, Jun</creator><creator>Wang, Bao-Jie</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove</general><general>Dove Medical 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Between Polymorphisms in the 5' Region of the GALR1 Gene and Schizophrenia in the Northern Chinese Han Population: A Case-Control Study</title><author>Li, Ya ; Gao, Meng ; Zeng, Kuo ; Xing, Jia-Xin ; Xu, Feng-Ling ; Xuan, Jin-Feng ; Xia, Xi ; Liu, Yong-Ping ; Yao, Jun ; Wang, Bao-Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-61cd22a727a18ed7d496af5026a53d12f3f507981f5a06503dd80b843da60ea23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Addictions</topic><topic>Age</topic><topic>Alleles</topic><topic>Alzheimer's disease</topic><topic>Analysis</topic><topic>Blood & organ donations</topic><topic>Central nervous system</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Dopamine</topic><topic>Epidemiology</topic><topic>Ethnicity</topic><topic>Females</topic><topic>Galanin</topic><topic>galanin receptor 1</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic factors</topic><topic>genetic polymorphism</topic><topic>Genetic research</topic><topic>Genotype & phenotype</topic><topic>Haplotypes</topic><topic>Males</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Mental health care</topic><topic>Nervous system</topic><topic>Neuropeptides</topic><topic>northern chinese han population</topic><topic>Original Research</topic><topic>Physiology</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism</topic><topic>Population</topic><topic>Population studies</topic><topic>Schizophrenia</topic><topic>Sex differences</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>single-nucleotide variant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ya</creatorcontrib><creatorcontrib>Gao, Meng</creatorcontrib><creatorcontrib>Zeng, Kuo</creatorcontrib><creatorcontrib>Xing, Jia-Xin</creatorcontrib><creatorcontrib>Xu, Feng-Ling</creatorcontrib><creatorcontrib>Xuan, Jin-Feng</creatorcontrib><creatorcontrib>Xia, Xi</creatorcontrib><creatorcontrib>Liu, Yong-Ping</creatorcontrib><creatorcontrib>Yao, Jun</creatorcontrib><creatorcontrib>Wang, Bao-Jie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) 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Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Neuropsychiatric disease and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ya</au><au>Gao, Meng</au><au>Zeng, Kuo</au><au>Xing, Jia-Xin</au><au>Xu, Feng-Ling</au><au>Xuan, Jin-Feng</au><au>Xia, Xi</au><au>Liu, Yong-Ping</au><au>Yao, Jun</au><au>Wang, Bao-Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Polymorphisms in the 5' Region of the GALR1 Gene and Schizophrenia in the Northern Chinese Han Population: A Case-Control Study</atitle><jtitle>Neuropsychiatric disease and treatment</jtitle><addtitle>Neuropsychiatr Dis Treat</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>16</volume><spage>1519</spage><epage>1532</epage><pages>1519-1532</pages><issn>1176-6328</issn><issn>1178-2021</issn><eissn>1178-2021</eissn><abstract>Epidemiological studies have shown that genetic factors are among the causes of schizophrenia. Galanin receptor 1 is an inhibitory receptor of galanin that is widely distributed in the central nervous system. This study mainly explored the relationship between polymorphisms of the 5' region of the
gene and schizophrenia in the northern Chinese Han population.
A 1545 bp fragment of the 5' regulatory region of the
gene was amplified and sequenced in 289 schizophrenia patients and 347 healthy controls.
Among the haplotypes composed of the 16 detected SNPs, the haplotype H3 was identified as conferring a risk of schizophrenia (
=0.011, OR=1.430, 95% CI=1.084-1.886). In addition, the haplotypes H4 and H7 were both protective against schizophrenia (
=0.024, OR=0.526, 95% CI=0.298-0.927;
=0.037, OR=0.197, 95% CI=0.044-0.885, respectively). In the subgroup analysis by sex, it was found that seven SNP alleles (rs72978691, rs11662010, rs11151014, rs11151015, rs13306374, rs5373, rs13306375) conferred a risk of schizophrenia in females (
<0.05), while allele G of rs7242919 (
=0.007) was protective against schizophrenia in females. Moreover, the rs72978691 AA+AC genotype (
=0.006, OR=1.874, 95% CI=1.196-2.937, power=0.780), rs7242919 CC+CG genotype (
=0.002, OR=2.027, 95% CI=1.292-3.180, power=0.861), rs11151014 GG+GT genotype (
=0.008, OR=1.834, 95% CI=1.168-2.879, power=0.735), rs11151015 GG+AG genotype (
=0.002, OR=2.013, 95% CI =1.291-3.137, power=0.843), rs13306374 CC+AC genotype (
=0.006, OR=1.881, 95% CI=1.198-2.953, power=0.788), and rs13306375 GG+AG genotype (
=0.006, OR=1.868, 95% CI=1.194-2.921, power=0.770) increased the risk of schizophrenia in females. The haplotype FH2 consisting of rs72978691, rs11662010, rs7242919, rs11151014, rs11151015, rs13306374, rs5373, and rs13306375 may also be associated with the risk of schizophrenia in females (
=0.024).
This study identified an association between polymorphisms in the 5' region of the
gene and schizophrenia, especially in females.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>32606704</pmid><doi>10.2147/NDT.S256644</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-0781-5694</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuropsychiatric disease and treatment, 2020-01, Vol.16, p.1519-1532 |
| issn | 1176-6328 1178-2021 1178-2021 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_1077b0c8f9c945b4bfc1a9af6d568deb |
| source | Publicly Available Content Database; Taylor & Francis Open Access Journals; PubMed Central |
| subjects | Addictions Age Alleles Alzheimer's disease Analysis Blood & organ donations Central nervous system Deoxyribonucleic acid DNA Dopamine Epidemiology Ethnicity Females Galanin galanin receptor 1 Gene expression Genes Genetic aspects Genetic factors genetic polymorphism Genetic research Genotype & phenotype Haplotypes Males Mental depression Mental disorders Mental health care Nervous system Neuropeptides northern chinese han population Original Research Physiology Polymerase chain reaction Polymorphism Population Population studies Schizophrenia Sex differences Single nucleotide polymorphisms Single-nucleotide polymorphism single-nucleotide variant |
| title | Association Between Polymorphisms in the 5' Region of the GALR1 Gene and Schizophrenia in the Northern Chinese Han Population: A Case-Control Study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T23%3A21%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20Between%20Polymorphisms%20in%20the%205'%20Region%20of%20the%20GALR1%20Gene%20and%20Schizophrenia%20in%20the%20Northern%20Chinese%20Han%20Population:%20A%20Case-Control%20Study&rft.jtitle=Neuropsychiatric%20disease%20and%20treatment&rft.au=Li,%20Ya&rft.date=2020-01-01&rft.volume=16&rft.spage=1519&rft.epage=1532&rft.pages=1519-1532&rft.issn=1176-6328&rft.eissn=1178-2021&rft_id=info:doi/10.2147/NDT.S256644&rft_dat=%3Cgale_doaj_%3EA631814173%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c573t-61cd22a727a18ed7d496af5026a53d12f3f507981f5a06503dd80b843da60ea23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2414111206&rft_id=info:pmid/32606704&rft_galeid=A631814173&rfr_iscdi=true |