Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case-control study

Calcific aortic valve stenosis (CAVS) represents a serious health threat to elderly patients. Post-stenotic aortic dilation, a common feature in CAVS patients, might progress into aneurysm and even dissection, potential consequences of CAVS, and predicts a poor prognosis. This study sought to invest...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2022-04, Vol.22 (1), p.195-195, Article 195
Main Authors: Chen, Shanghao, Wu, Zezhong, Yun, Yan, Shen, Hechen, Zhao, Diming, Liu, Yanwu, Zou, Chengwei, Zhang, Haizhou, Wang, Zhengjun, Ma, Xiaochun
Format: Article
Language:English
Subjects:
Aged
Aneurysms
Aorta
Aortic stenosis
Aortic valve
Aortic Valve - pathology
Aortic Valve Stenosis
Association
Biomarkers
Calcinosis
Cardiac arrhythmia
Cardiovascular disease
Care and treatment
Case-Control Studies
Coronary vessels
Diabetes
Diagnosis
Diagnostic tests
Dilatation
Dilatation, Pathologic
Endocarditis
Health aspects
Humans
Hypertension
Inflammation
Lymphocyte-to-monocyte ratio
Lymphocytes
Measurement
Medical prognosis
Monocytes
Multivariate analysis
Normal distribution
Pathophysiology
Population studies
Post-stenotic aortic dilation
Prevention
Retrospective Studies
Risk factors
Statistical analysis
Stenosis
Vein & artery diseases
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Summary:Calcific aortic valve stenosis (CAVS) represents a serious health threat to elderly patients. Post-stenotic aortic dilation, a common feature in CAVS patients, might progress into aneurysm and even dissection, potential consequences of CAVS, and predicts a poor prognosis. This study sought to investigate the association of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, with severe post-stenotic aortic dilation in a case-control study in Chinese population. 208 consecutive patients with CAVS were recruited retrospectively in a case-control study in Chinese population, from July 1, 2015 to June 31, 2018. LMR was statistically analyzed using the ROC curve and binary logistic regression analyses for its prognostic value in severe post-stenotic aortic dilation. LMR was significantly reduced in patients with severe post-stenotic aortic dilation (2.72 vs. 3.53, p = 0.002 
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-022-02636-3