Postoperative pancreatic fistula affects recurrence-free survival of pancreatic cancer patients

Postoperative pancreatic fistula (POPF) with reported incidence rates up to 45% contributes substantially to overall morbidity. In this study, we conducted a retrospective evaluation of POPF along with its potential perioperative clinical risk factors and its effect on tumor recurrence. Clinical dat...

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Bibliographic Details
Published in:PloS one 2021-06, Vol.16 (6), p.e0252727
Main Authors: Dhayat, Sameer A, Tamim, Ahmad N J, Jacob, Marius, Ebeling, Georg, Kerschke, Laura, Kabar, Iyad, Senninger, Norbert
Format: Article
Language:English
Subjects:
Aged
Cancer
Care and treatment
Complications
Disease-Free Survival
Female
Fistula
Humans
Male
Medicine and Health Sciences
Middle Aged
Neoplasm Recurrence, Local - pathology
Pancreatectomy - adverse effects
Pancreatic cancer
Pancreatic Fistula - etiology
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Pancreaticoduodenectomy - adverse effects
Physical Sciences
Postoperative Complications - etiology
Relapse
Research and Analysis Methods
Retrospective Studies
Risk Factors
Surgery
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Summary:Postoperative pancreatic fistula (POPF) with reported incidence rates up to 45% contributes substantially to overall morbidity. In this study, we conducted a retrospective evaluation of POPF along with its potential perioperative clinical risk factors and its effect on tumor recurrence. Clinical data on patients who had received pancreatoduodenectomy (PD), distal pancreatectomy (DP), or duodenum-preserving pancreatic head resection (DPPHR) were prospectively collected between 2007 and 2016. A Picrosirius red staining score was developed to enable morphological classification of the resection margin of the pancreatic stump. The primary end point was the development of major complications. The secondary end points were overall and recurrence-free survival. 340 patients underwent pancreatic resection including 222 (65.3%) PD, 87 (25.6%) DP, and 31 (9.1%) DPPHR. Postoperative major complications were observed in 74 patients (21.8%). In multivariable logistic regression analysis, POPF correlated with body mass index (BMI) (p = 0.025), prolonged stay in hospital (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0252727