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The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves' disease: a case report
Hyperthyroidism-induced hypercalcemia has been reported previously, but hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement in patients with hyperthyroidism is quite rare. We report the coexistence of hypercalcemia, osteoporosis and thymic enlargement in a patient wit...
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| Published in: | BMC endocrine disorders 2020-06, Vol.20 (1), p.97-97, Article 97 |
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| creator | Yan, Dandan Xu, Yanjun Li, Lian-Xi |
| description | Hyperthyroidism-induced hypercalcemia has been reported previously, but hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement in patients with hyperthyroidism is quite rare. We report the coexistence of hypercalcemia, osteoporosis and thymic enlargement in a patient with Graves' disease.
A 22-year-old female was diagnosed as Graves' disease with obviously elevated serum calcium and reduced parathyroid hormone levels. Dual-energy x-ray absorptiometry and chest enhanced computer tomography (CT) revealed severe osteoporosis and a significant enlargement of thymus. After the successful control of hyperthyroidism with methimazole, hypercalcemia was corrected, bone mineral density was improved and thymus also shrank obviously.
This is a very rare case of hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement induced by Graves' disease. In clinical practice, examination of thymus and bone density should be considered when a patient with Graves' disease was present with hypercalcemia. |
| doi_str_mv | 10.1186/s12902-020-00583-8 |
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A 22-year-old female was diagnosed as Graves' disease with obviously elevated serum calcium and reduced parathyroid hormone levels. Dual-energy x-ray absorptiometry and chest enhanced computer tomography (CT) revealed severe osteoporosis and a significant enlargement of thymus. After the successful control of hyperthyroidism with methimazole, hypercalcemia was corrected, bone mineral density was improved and thymus also shrank obviously.
This is a very rare case of hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement induced by Graves' disease. In clinical practice, examination of thymus and bone density should be considered when a patient with Graves' disease was present with hypercalcemia.</description><identifier>ISSN: 1472-6823</identifier><identifier>EISSN: 1472-6823</identifier><identifier>DOI: 10.1186/s12902-020-00583-8</identifier><identifier>PMID: 32605565</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Bone mineral density ; Calcium ; Calcium (blood) ; Case Report ; Case reports ; CAT scans ; Coexistence ; Diagnosis ; Diagnostic imaging ; Disease ; Dual energy X-ray absorptiometry ; Enlargement ; Female ; Graves Disease - physiopathology ; Graves' disease ; Hormones ; Humans ; Hypercalcemia ; Hypercalcemia - complications ; Hypercalcemia - pathology ; Hyperplasia ; Hyperthyroidism ; Laboratories ; Liver ; Metabolism ; Methimazole ; Osteoporosis ; Osteoporosis - complications ; Osteoporosis - pathology ; Parathyroid ; Parathyroid hormone ; Patients ; Phosphorus ; Prognosis ; Scintigraphy ; Thymic enlargement ; Thymus ; Thymus gland ; Thymus Hyperplasia - complications ; Thymus Hyperplasia - pathology ; Thyroid diseases ; Thyroid gland ; Young Adult</subject><ispartof>BMC endocrine disorders, 2020-06, Vol.20 (1), p.97-97, Article 97</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-a92c81d909ea72e88417ccb8ec1815c4a81db0a23777d38b8b65c37eeae99df83</citedby><cites>FETCH-LOGICAL-c563t-a92c81d909ea72e88417ccb8ec1815c4a81db0a23777d38b8b65c37eeae99df83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324972/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2424774082?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32605565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Dandan</creatorcontrib><creatorcontrib>Xu, Yanjun</creatorcontrib><creatorcontrib>Li, Lian-Xi</creatorcontrib><title>The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves' disease: a case report</title><title>BMC endocrine disorders</title><addtitle>BMC Endocr Disord</addtitle><description>Hyperthyroidism-induced hypercalcemia has been reported previously, but hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement in patients with hyperthyroidism is quite rare. We report the coexistence of hypercalcemia, osteoporosis and thymic enlargement in a patient with Graves' disease.
A 22-year-old female was diagnosed as Graves' disease with obviously elevated serum calcium and reduced parathyroid hormone levels. Dual-energy x-ray absorptiometry and chest enhanced computer tomography (CT) revealed severe osteoporosis and a significant enlargement of thymus. After the successful control of hyperthyroidism with methimazole, hypercalcemia was corrected, bone mineral density was improved and thymus also shrank obviously.
This is a very rare case of hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement induced by Graves' disease. In clinical practice, examination of thymus and bone density should be considered when a patient with Graves' disease was present with hypercalcemia.</description><subject>Adult</subject><subject>Bone mineral density</subject><subject>Calcium</subject><subject>Calcium (blood)</subject><subject>Case Report</subject><subject>Case reports</subject><subject>CAT scans</subject><subject>Coexistence</subject><subject>Diagnosis</subject><subject>Diagnostic imaging</subject><subject>Disease</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Enlargement</subject><subject>Female</subject><subject>Graves Disease - physiopathology</subject><subject>Graves' disease</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypercalcemia</subject><subject>Hypercalcemia - complications</subject><subject>Hypercalcemia - pathology</subject><subject>Hyperplasia</subject><subject>Hyperthyroidism</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Methimazole</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis - pathology</subject><subject>Parathyroid</subject><subject>Parathyroid hormone</subject><subject>Patients</subject><subject>Phosphorus</subject><subject>Prognosis</subject><subject>Scintigraphy</subject><subject>Thymic enlargement</subject><subject>Thymus</subject><subject>Thymus gland</subject><subject>Thymus Hyperplasia - complications</subject><subject>Thymus Hyperplasia - pathology</subject><subject>Thyroid diseases</subject><subject>Thyroid gland</subject><subject>Young Adult</subject><issn>1472-6823</issn><issn>1472-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAQjRCIlsIf4IAscYADKf5I_MEBqar4qFSJSzlbE2eSdZXYi52t2H-Pt1uqXYR8GGvmzRvNm1dVrxk9Z0zLj5lxQ3lNOa0pbbWo9ZPqlDWK11Jz8fTgf1K9yPmWUqY0p8-rE8ElbVvZnlbjzQqJi_jb5wWDQxIHstquMTmYHM4ePpBYKnEdU8w-Ewg9WVbb2TuCYYI04oxhIT6QMcEd5nek9xkh4ycCxJVIEpbe5WX1bIAp46uHeFb9_Prl5vJ7ff3j29XlxXXtWimWGgx3mvWGGgTFUeuGKec6jY5p1roGSrGjwIVSqhe6051snVCIgMb0gxZn1dWet49wa9fJz5C2NoK394mYRgtp8W5Cy6jWg5GDM1I2sgzrWq4Yk0pCEc40hevznmu96WbsXVk0wXREelwJfmXHeGeV4I1RvBC8fyBI8dcG82Jnnx1OEwSMm2x5w0zDqDA76Nt_oLdxk0KRqqB4o1RD9QFqhLKAD0Msc92O1F5Irsu5W8MK6vw_qPL6clAXAw6-5I8a-L7BlSPnhMPjjozandXs3mq2WM3eW83ulH5zqM5jy19viT8K1c2g</recordid><startdate>20200630</startdate><enddate>20200630</enddate><creator>Yan, Dandan</creator><creator>Xu, Yanjun</creator><creator>Li, Lian-Xi</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200630</creationdate><title>The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves' disease: a case report</title><author>Yan, Dandan ; Xu, Yanjun ; Li, Lian-Xi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-a92c81d909ea72e88417ccb8ec1815c4a81db0a23777d38b8b65c37eeae99df83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Bone mineral density</topic><topic>Calcium</topic><topic>Calcium (blood)</topic><topic>Case Report</topic><topic>Case reports</topic><topic>CAT scans</topic><topic>Coexistence</topic><topic>Diagnosis</topic><topic>Diagnostic imaging</topic><topic>Disease</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Enlargement</topic><topic>Female</topic><topic>Graves Disease - physiopathology</topic><topic>Graves' disease</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypercalcemia</topic><topic>Hypercalcemia - complications</topic><topic>Hypercalcemia - pathology</topic><topic>Hyperplasia</topic><topic>Hyperthyroidism</topic><topic>Laboratories</topic><topic>Liver</topic><topic>Metabolism</topic><topic>Methimazole</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis - pathology</topic><topic>Parathyroid</topic><topic>Parathyroid hormone</topic><topic>Patients</topic><topic>Phosphorus</topic><topic>Prognosis</topic><topic>Scintigraphy</topic><topic>Thymic enlargement</topic><topic>Thymus</topic><topic>Thymus gland</topic><topic>Thymus Hyperplasia - complications</topic><topic>Thymus Hyperplasia - pathology</topic><topic>Thyroid diseases</topic><topic>Thyroid gland</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Dandan</creatorcontrib><creatorcontrib>Xu, Yanjun</creatorcontrib><creatorcontrib>Li, Lian-Xi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC endocrine disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Dandan</au><au>Xu, Yanjun</au><au>Li, Lian-Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves' disease: a case report</atitle><jtitle>BMC endocrine disorders</jtitle><addtitle>BMC Endocr Disord</addtitle><date>2020-06-30</date><risdate>2020</risdate><volume>20</volume><issue>1</issue><spage>97</spage><epage>97</epage><pages>97-97</pages><artnum>97</artnum><issn>1472-6823</issn><eissn>1472-6823</eissn><abstract>Hyperthyroidism-induced hypercalcemia has been reported previously, but hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement in patients with hyperthyroidism is quite rare. We report the coexistence of hypercalcemia, osteoporosis and thymic enlargement in a patient with Graves' disease.
A 22-year-old female was diagnosed as Graves' disease with obviously elevated serum calcium and reduced parathyroid hormone levels. Dual-energy x-ray absorptiometry and chest enhanced computer tomography (CT) revealed severe osteoporosis and a significant enlargement of thymus. After the successful control of hyperthyroidism with methimazole, hypercalcemia was corrected, bone mineral density was improved and thymus also shrank obviously.
This is a very rare case of hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement induced by Graves' disease. In clinical practice, examination of thymus and bone density should be considered when a patient with Graves' disease was present with hypercalcemia.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>32605565</pmid><doi>10.1186/s12902-020-00583-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Bone mineral density Calcium Calcium (blood) Case Report Case reports CAT scans Coexistence Diagnosis Diagnostic imaging Disease Dual energy X-ray absorptiometry Enlargement Female Graves Disease - physiopathology Graves' disease Hormones Humans Hypercalcemia Hypercalcemia - complications Hypercalcemia - pathology Hyperplasia Hyperthyroidism Laboratories Liver Metabolism Methimazole Osteoporosis Osteoporosis - complications Osteoporosis - pathology Parathyroid Parathyroid hormone Patients Phosphorus Prognosis Scintigraphy Thymic enlargement Thymus Thymus gland Thymus Hyperplasia - complications Thymus Hyperplasia - pathology Thyroid diseases Thyroid gland Young Adult |
| title | The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves' disease: a case report |
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