Colchicine therapy in amyloidosis related with plasmacytic castleman disease presenting with nephrotic syndrome

• Published in: Saudi journal of kidney diseases and transplantation 2015-09, Vol.26 (5), p.992-995
• Main Authors: Paydas, Saime, Paydas, Semra, Ergin, Melek
• Format: Article
• Language: English
• Subjects: Abdomen; ADP-ribosyl Cyclase 1 - analysis; Adult; Amyloidosis; Amyloidosis - diagnosis; Amyloidosis - drug therapy; Amyloidosis - etiology; Amyloidosis - immunology; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Biopsy; Case studies; Castleman Disease - complications; Castleman Disease - diagnosis; Castleman Disease - immunology; Castleman Disease - surgery; Colchicine; Colchicine - therapeutic use; Conflicts of interest; Disease; Dosage and administration; Drug therapy; Drug Therapy, Combination; Edema; Humans; Immunohistochemistry; Lymphatic system; Lymphoproliferative disorders; Male; Medical prognosis; Membrane Glycoproteins - analysis; Nephrotic syndrome; Nephrotic Syndrome - diagnosis; Nephrotic Syndrome - drug therapy; Nephrotic Syndrome - etiology; Nephrotic Syndrome - immunology; Serum Amyloid A Protein - analysis; Time Factors; Tomography; Treatment; Treatment Outcome; الأيض; البروتينات; الداء النشواني; الكولشيسين; المتلازمة الكلوية; علم المداواة
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.164589

Castleman disease (CD) is a neoplasm that presents with single or multiple lymphadenopathy. The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy. In this paper, we report a young man with plasmacytic type CD and amyloid A (AA) deposition who presented with intra-abdominal mass and nephrotic syndrome. He was successfully treated with colchicine following surgery.