Immunodetection of Tau microtubule-associated protein in human sperm and testis

Dear Editor, The cytosolic protein Tau is naturally present in human neurons, where it has a pivotal role in controlling microtubule stability. Hyperphosphorylation of Tau （observed during neurodegenerative diseases, such as Alzheimer＇s disease） impairs the protein＇s ability to bind microtubules. Th...

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Bibliographic Details
Published in:Asian journal of andrology 2014-11, Vol.16 (6), p.927-928
Main Authors: Sigala, Julien, Jumeau, Fanny, Caillet-Boudin, Marie-Laure, Sergeant, Nicolas, Ballot, Caroline, Rigot, Jean-Marc, Marcelli, François, Tardivel, Meryem, Buée, Luc, Mitchell, Valérie
Format: Article
Language:English
Subjects:
Alzheimer's disease
Experiments
Humans
Laboratories
Letter to the Editor
Male
Medical research
Men
Protein binding
Proteins
Reproductive system
Rodents
Sperm
Spermatozoa - metabolism
Studies
tau Proteins - metabolism
Tau蛋白
Testis - metabolism
人精子
免疫检测
微管相关蛋白
特异性抗体
睾丸组织
神经变性疾病
阿尔茨海默氏病
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Summary:Dear Editor, The cytosolic protein Tau is naturally present in human neurons, where it has a pivotal role in controlling microtubule stability. Hyperphosphorylation of Tau （observed during neurodegenerative diseases, such as Alzheimer＇s disease） impairs the protein＇s ability to bind microtubules. This results in microtubule disassembly and the formation of Tau aggregates, Tau protein is also widely expressed in peripheral tissues. In the male reproductive system, screening for Tau has focused solely on the rodent and bovine testis. In the present study, we used immunofluorescence and immunoenzymatic techniques （with a Tau-specific antibody） to investigate the presence of Tau protein in human ejaculated sperm and testicular tissue.
ISSN:1008-682X
1745-7262
DOI:10.4103/1008-682X.136446