T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

T cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentiation and function of T cells in immune response. I...

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Bibliographic Details
Published in:Frontiers in immunology 2023-02, Vol.14, p.1104771-1104771
Main Authors: Chi, Xiaoxia, Luo, Shahang, Ye, Peng, Hwang, Wei-Lun, Cha, Jong-Ho, Yan, Xiuwen, Yang, Wen-Hao
Format: Article
Language:English
Subjects:
cancer immunotherapy
Cell Differentiation
chronic antigenic stimulation
exhaustion
Humans
Immunology
Immunotherapy
Neoplasms - therapy
stemness
T-Cell Exhaustion
T-Lymphocytes
TSCM
Tumor Microenvironment
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Summary:T cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentiation and function of T cells in immune response. In this review, we describe the research progress on T-cell exhaustion and stemness in the field of cancer immunotherapy and summarize advances in potential strategies to intervene and treat chronic infection and cancer by reversing T-cell exhaustion and maintaining and increasing T-cell stemness. Moreover, we discuss therapeutic strategies to overcome T-cell immunodeficiency in the tumor microenvironment and promote continuous breakthroughs in the anticancer activity of T cells.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1104771