Monocytic MDSC mobilization promotes tumor recurrence after liver transplantation via CXCL10/TLR4/MMP14 signaling

Tumor recurrence is the major obstacle for pushing the envelope of liver transplantation for hepatocellular carcinoma (HCC) patients. The inflammatory cascades activated by acute liver graft injury promote tumor recurrence. We aimed to explore the role and mechanism of myeloid-derived suppressor cel...

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Bibliographic Details
Published in:Cell death & disease 2021-05, Vol.12 (5), p.489-489, Article 489
Main Authors: Liu, Hui, Ling, Chang Chun, Yeung, Wai Ho Oscar, Pang, Li, Liu, Jiang, Zhou, Jie, Zhang, Wei Yi, Liu, Xiao Bing, Ng, Tak Pan Kevin, Yang, Xin Xiang, Lo, Chung Mau, Man, Kwan
Format: Article
Language:English
Subjects:
13/1
13/106
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14
14/19
38
38/39
38/47
38/77
64/60
692/308/1426
692/699/1503/1607/1610
Antibodies
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
CXCL10 protein
Hepatectomy
Hepatocellular carcinoma
Immunology
Inflammation
Ischemia
Life Sciences
Liver
Liver cancer
Liver transplantation
Liver transplants
Monocytes
Reperfusion
TLR4 protein
Toll-like receptors
Transplants & implants
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Summary:Tumor recurrence is the major obstacle for pushing the envelope of liver transplantation for hepatocellular carcinoma (HCC) patients. The inflammatory cascades activated by acute liver graft injury promote tumor recurrence. We aimed to explore the role and mechanism of myeloid-derived suppressor cell (MDSC) mobilization induced by liver graft injury on tumor recurrence. By analyzing 331 HCC patients who received liver transplantation, the patients with graft weight ratio (GWR, the weight of liver graft divided by the estimated standard liver weight of recipient)
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-021-03788-4