Modulatory activity of brazilian red propolis on chemically induced dermal carcinogenesis

PURPOSE:To evaluate modulatory effects of a hydroalcoholic extract of Brazilian red propolis (HERP) on dermal carcinogenesis using a murine model.METHODS: The HERP was used at concentrations of 10, 50 and 100 mg/kg (PROP10, PROP50 and PROP100, respectively) to modulate dermal carcinogenesis induced...

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Published in:Acta cirúrgica brasileira 2014-02, Vol.29 (2), p.111-117
Main Authors: Pinheiro, Kariny Souza, Ribeiro, Danielle Rodrigues, Alves, Angela Valéria Farias, Pereira-Filho, Rose Nely, Oliveira, Clauberto Rodrigues de, Lima, Sônia Oliveira, Reis, Francisco Prado, Cardoso, Juliana Cordeiro, Albuquerque-Júnior, Ricardo Luiz Cavalcanti de
Format: Article
Language:English
Subjects:
DMBA
Propolis
Rodents
Skin Cancer
Squamous Cell Cancer
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Summary:PURPOSE:To evaluate modulatory effects of a hydroalcoholic extract of Brazilian red propolis (HERP) on dermal carcinogenesis using a murine model.METHODS: The HERP was used at concentrations of 10, 50 and 100 mg/kg (PROP10, PROP50 and PROP100, respectively) to modulate dermal carcinogenesis induced by the application of 9,10-dimetil-1,2-benzatraceno (DMBA) on the backs of animals.RESULTS:The chemical compounds identified in HERP included propyl gallate, catechin, epicatechin and formononetin. PROP100 treatment resulted in significantly decreased tumor multiplicity throughout the five weeks of tumor promotion (p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-86502014000200007