The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response

This review provides an overview on components of the sphingolipid superfamily, on their localization and metabolism. Information about the sphingolipid biological activity in cell physiopathology is given. Recent studies highlight the role of sphingolipids in inflammatory process. We summarize the...

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Bibliographic Details
Published in:Mediators of inflammation 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Grösch, S., Albi, Elisabetta, Alessenko, Alice
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biological activity
Cell Differentiation - physiology
Cell migration
Cell Movement - physiology
Enzymes
Gangliosides
Humans
Inflammation
Inflammation - metabolism
Kinases
Lipid metabolism
Lipids
Localization
Membranes
Neutrophils
Phosphates
Physiological aspects
Proteins
Review
Reviews
Signal transduction
Sphingolipids
Sphingolipids - metabolism
Sphingosine
Tumor necrosis factor-TNF
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Summary:This review provides an overview on components of the sphingolipid superfamily, on their localization and metabolism. Information about the sphingolipid biological activity in cell physiopathology is given. Recent studies highlight the role of sphingolipids in inflammatory process. We summarize the emerging data that support the different roles of the sphingolipid members in specific phases of inflammation: (1) migration of immune cells, (2) recognition of exogenous agents, and (3) activation/differentiation of immune cells.
ISSN:0962-9351
1466-1861
DOI:10.1155/2018/5378284