Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells

Crohn's disease activates the inflammatory reactions to induce intestinal disorders. Enteral nutrition (EN) could exert general immunomodulatory effects. Cecal ligation and perforation (CLP) surgery was utilized to establish Crohn's disease mice models. Survival analysis, hematoxylin-eosin...

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Bibliographic Details
Published in:Innate immunity (London, England) England), 2021-10, Vol.27 (7-8), p.533-542
Main Authors: Zhao, Di, Yang, Bo, Ye, Chen, Zhang, Shaoyi, Lv, Xiaoqiong, Chen, Qiyi
Format: Article
Language:English
Subjects:
Animal models
Animals
Cecum
Crohn Disease - therapy
Crohn's disease
Enteral Nutrition
Enzyme-linked immunosorbent assay
Flow cytometry
Immunity, Innate
Immunomodulation
Inflammatory bowel diseases
Interleukin 6
Leukocytes (neutrophilic)
Liquid chromatography
Lymphocytes
Lymphoid cells
Mice
Original
Peritoneum
Serum levels
Survival analysis
Tumor Necrosis Factor-alpha
Tumor necrosis factor-α
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Summary:Crohn's disease activates the inflammatory reactions to induce intestinal disorders. Enteral nutrition (EN) could exert general immunomodulatory effects. Cecal ligation and perforation (CLP) surgery was utilized to establish Crohn's disease mice models. Survival analysis, hematoxylin-eosin staining, flow cytometry, ELISA, Western blot and liquid chromatography-tandem MS were applied. Baicalein was added to inhibit lipoxygenases. The survival rate was restored and inflammatory injury, exudate neutrophils in peritoneal lavage and serum levels of IL-6 and TNF-α were ameliorated by EN treatment as compared with CLP treatment. EN also increased ILC-3 content, 5/15-LOX level and RvD1-RvD5 in peritoneal lavage. Baicalein reversed all the detected effects of EN except ILC-3 content. EN could activate special pro-resolving mediators (SPMs) through ILCs to mitigate injuries of Crohn's disease.
ISSN:1753-4259
1753-4267
DOI:10.1177/17534259211057038