Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina

Objective. To describe bacterial resistance and antimicrobial consumption ratio at the subnational level in Argentina during 2018, considering beta-lactams group as a case-study. Methods. Antimicrobial consumption was expressed as defined daily doses (DDD)/1000 inhabitants. Resistance of Escherichia...

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Bibliographic Details
Published in:Revista panamericana de salud pública 2021-01, Vol.45 (76), p.1-e76
Main Authors: Boni, Silvia, Marin, Gustavo H., Campaña, Laura, Marin, Lupe, Corso, Alejandra, Risso-Patron, Soledad, Gabriel, Fernanda, Garay, Valeria, Limeres, Manuel
Format: Article
Language:English
Subjects:
Antimicrobial agents
argentina
Bacteria
beta-lactams
Comparative studies
Consumption
Dosage
Drug resistance
drug resistance, microbial
E coli
Escherichia coli
First generation
Health Policy & Services
Management
Original Research
Penicillin
Sales
Second generation
Streptococcus infections
Third generation
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Summary:Objective. To describe bacterial resistance and antimicrobial consumption ratio at the subnational level in Argentina during 2018, considering beta-lactams group as a case-study. Methods. Antimicrobial consumption was expressed as defined daily doses (DDD)/1000 inhabitants. Resistance of Escherichia coli, Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus to beta-lactams was recorded. Resistance/consumption ratio was estimated calculating “R” for each region of Argentina, and this data was compared with other countries. Results. The most widely consumed beta-lactams in Argentina were amoxicillin (3.64) for the penicillin sub-group, cephalexin (0.786) for first generation cephalosporins, cefuroxime (0.022) for second generation; cefixime (0.043) for third generation and cefepime (0.0001) for the fourth generation group. Comparison between beta-lactams consumption and bacterial resistance demonstrated great disparities between the six regions of the country. Conclusions. The case-study of Argentina shows that antimicrobial consumption and resistance of the most common pathogens differed among regions, reflecting different realities within the same country. Because this situation might also be occurring in other countries, this data should be taken into account to target local efforts towards better antimicrobial use, to improve antimicrobial stewardship programs and to propose more suitable sales strategies in order to prevent and control antimicrobial resistance.
ISSN:1020-4989
1680-5348
1680-5348
DOI:10.26633/RPSP.2021.76