Combination treatment with whole body vibration and simvastatin improves the early osseointegration in aged rats

• Published in: Bone Reports 2024-09, Vol.22, p.101790, Article 101790
• Main Authors: Qiao, Zheng-Bo, Gu, Ming-Zhong, Wang, Yu-Wu, Ma, Bin-Bin, Pang, Shan-Shan
• Format: Article
• Language: English
• Subjects: Bone loss; Full Length; Osseointegration; Oxidative stress; Simvastatin; Whole body vibration
• ISSN: 2352-1872; 2352-1872
• DOI: 10.1016/j.bonr.2024.101790

Current research has demonstrated that Simvastatin (SIM) and Whole Body Vibration (WBV) actively contributes to the repair of osteoporotic bones. However, there is still limited knowledge regarding the impact of this combined therapy on osseointegration in elderly individuals. Objective: The objective of this study was to verify the influence of WBV and SIM combination treatment on Titanium implants' fixation strength in aged rats. Male Sprague-Dawley rats at 24 months old were utilized for this investigation. Titanium rods were surgically inserted into the distal femoral canal on their left side. Subsequently, all animals were randomly assigned to one of four groups: Control group; WBV group; SIM group; and WBV + SIM group. Each group received Saline, Whole Body Vibration, Simvastatin, or a combination of Whole Body Vibration plus Simvastatin treatment until they reached their natural death after 12 weeks. The bilateral femurs and serum samples from these rats were collected for evaluation purposes. Both WBV and SIM treatments exhibited an increase in bone mass, osseointegration, and push-out force compared to the Control group (all, P