The Rise of Coccidioides : Forces Against the Dust Devil Unleashed

Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of or . This neglected disease occurs in the desert areas of the western United States, most notably in California and Arizona, where infections continue to rise. Clinically, coccidioidomycosis ranges from asymptomatic to...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2019-09, Vol.10, p.2188-2188
Main Authors: Van Dyke, Marley C Caballero, Thompson, George R, Galgiani, John N, Barker, Bridget M
Format: Article
Language:English
Subjects:
antifungal drugs
Coccidioides
fungal vaccines
immunity
Immunology
valley fever
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Coccidioidomycosis (Valley fever) is a fungal disease caused by the inhalation of or . This neglected disease occurs in the desert areas of the western United States, most notably in California and Arizona, where infections continue to rise. Clinically, coccidioidomycosis ranges from asymptomatic to severe pulmonary disease and can disseminate to the brain, skin, bones, and elsewhere. New estimates suggest as many as 350,000 new cases of coccidioidomycosis occur in the United States each year. Thus, there is an urgent need for the development of a vaccine and new therapeutic drugs against infection. In this review, we discuss the battle against including the development of potential vaccines, the quest for new therapeutic drugs, and our current understanding of the protective host immune response to infection.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.02188