Acute Tramadol-Induced Cellular Tolerance and Dependence of Ventral Tegmental Area Dopaminergic Neurons: An in Vivo Electrophysiological Study

Introduction: Ventral Tegmental Area (VTA) is a core region of the brainstem that contributes to different vital bio-responses such as pain and addiction. The Dopaminergic (DA) cellular content of VTA has major roles in different functions. This study aims to evaluate the cellular effect of tramadol...

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Bibliographic Details
Published in:Basic and clinical neuroscience 2019-05, Vol.10 (3), p.209-224
Main Authors: Khodayari, Shabnam, Ghaderi Pakdel, Firouz, Shahabi, Parviz, Naderi, Somayyeh
Format: Article
Language:English
Subjects:
Addictions
Brain stem
Dependence
Dopamine
Dopamine receptors
Drug tolerance
Electrophysiological recording
Firing rate
Injection
Narcotics
Neurons
Neurotransmission
Opioids
Pain
Research Paper
Tolerance
Tramadol
Ventral Tegmental Area
Ventral tegmentum
Withdrawal
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Summary:Introduction: Ventral Tegmental Area (VTA) is a core region of the brainstem that contributes to different vital bio-responses such as pain and addiction. The Dopaminergic (DA) cellular content of VTA has major roles in different functions. This study aims to evaluate the cellular effect of tramadol on the putative VTA-DA neurons.Methods: Wistar rats were assigned into three groups of control, sham, and tramadol-treated. The animals were anesthetized and their VTA-DA neuronal activity was obtained under controlled stereotaxic operation. The firing rate of the neurons was extracted according to principal component analysis by Igor Pro software and analyzed statistically considering P
ISSN:2228-7442
2008-126X
2228-7442
DOI:10.32598/bcn.9.10.180