Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases

Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD), and the risk of CVD increases with reductions in renal function. This study aims to investigate the potential roles of B lymphocyte populations in subclinical atherosclerosis (measured by inti...

Full description

Saved in:
Bibliographic Details
Published in:BMC nephrology 2021-11, Vol.22 (1), p.396-396, Article 396
Main Authors: Lin, Jieshan, Tang, Bin, Feng, Zhanwu, Hao, Wenke, Hu, Wenxue
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged patients
Aged, 80 and over
Antibodies
Arteriosclerosis
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - epidemiology
Atherosclerosis - etiology
B cells
B-Lymphocyte Subsets
Beta cells
Blood
Blood cell count
Blood pressure
Cardiovascular diseases
Carotid arteries
CD19 antigen
CD5 antigen
Chronic kidney disease
Chronic kidney failure
Complications and side effects
Correlation analysis
Creatinine
Diabetes
Diabetes mellitus
Elderly
Female
Flow cytometry
Health aspects
Humans
Hypertension
Immune system
Intima-media thickness
Kidney diseases
Lymphocyte Count
Lymphocytes
Male
Medical examination
Medical prognosis
Mortality
Multiple regression analysis
Nephrology
Patients
Prognosis
Regression analysis
Renal function
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
Retrospective Studies
Risk Assessment
Risk factors
Severity of Illness Index
Software
Survival analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD), and the risk of CVD increases with reductions in renal function. This study aims to investigate the potential roles of B lymphocyte populations in subclinical atherosclerosis (measured by intima-media thickness, IMT) and prognosis in elderly patients with moderate-to-severe CKD. In this study, a total of 219 patients (143 moderate-to-severe CKD patients with stage 3-4 and 76 non-CKD controls) were recruited. B cell subsets: CD19(+)CD5(+) and CD19(+)CD5(-) B cells were analyzed by flow cytometry. Intima-media thickness (IMT) was measured by ultrasound. Correlations between the B cell subsets with IMT and clinical outcome was analyzed. CKD patients showed increased IMT (P = 0.006). The level of CD19(+)CD5(+) and CD19(+)CD5(-) B cells were decreased in CKD patients. Correlation analysis showed that IMT was positively correlated with systolic blood pressure, protein/creatinine ratio and diabetes (P 
ISSN:1471-2369
1471-2369
DOI:10.1186/s12882-021-02613-6