Preparation of Chito-Oligomers by Hydrolysis of Chitosan in the Presence of Zeolite as Adsorbent

An increasing interest has recently been shown to use chitin/chitosan oligomers (chito-oligomers) in medicine and food fields because they are not only water-soluble, nontoxic, and biocompatible materials, but they also exhibit numerous biological properties, including antibacterial, antifungal, and...

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Bibliographic Details
Published in:Marine drugs 2016-07, Vol.14 (8), p.43-43
Main Authors: Ibrahim, Khalid A, El-Eswed, Bassam I, Abu-Sbeih, Khaleel A, Arafat, Tawfeeq A, Al Omari, Mahmoud M H, Darras, Fouad H, Badwan, Adnan A
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Antifungal Agents - chemistry
Antineoplastic Agents - chemistry
Biocompatible Materials - chemistry
Brackish
Calorimetry, Differential Scanning
Chitin - chemistry
chito-oligomers
chitosan
Chitosan - chemistry
Chromatography, Liquid
depolymerization
Hydrochloric Acid - chemistry
Hydrolysis
Indicators and Reagents - chemistry
Marine
Mass Spectrometry
Ninhydrin - chemistry
zeolite
Zeolites - chemistry
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Summary:An increasing interest has recently been shown to use chitin/chitosan oligomers (chito-oligomers) in medicine and food fields because they are not only water-soluble, nontoxic, and biocompatible materials, but they also exhibit numerous biological properties, including antibacterial, antifungal, and antitumor activities, as well as immuno-enhancing effects on animals. Conventional depolymerization methods of chitosan to chito-oligomers are either chemical by acid-hydrolysis under harsh conditions or by enzymatic degradation. In this work, hydrolysis of chitosan to chito-oligomers has been achieved by applying adsorption-separation technique using diluted HCl in the presence of different types of zeolite as adsorbents. The chito-oligomers were retrieved from adsorbents and characterized by differential scanning calorimetry (DSC), liquid chromatography/mass spectroscopy (LC/MS), and ninhydrin test.
ISSN:1660-3397
1660-3397
DOI:10.3390/md14080043