Intraoperative fluorescence-guided resection of high-grade glioma: A systematic review

High-grade glioma (HGG) is a devastating disease with very poor prognosis. Maximal resection of HGG improves survival and maximal visualization of the tumor, if reliable, improves the resection. Fluorescence is widely used as guidance mechanism and has demonstrated potential in maximizing the extent...

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Bibliographic Details
Published in:Glioma (Mumbai, India) India), 2018-01, Vol.1 (6), p.189-195
Main Authors: Yang, Lin, Xiang, Yan, Huang, Guo-Hao, Lyu, Hong-Yao, Mou, Ke-Jie, Lv, Sheng-Qing
Format: Article
Language:English
Subjects:
Fluorescence-guided resection
malignant glioma
total removal
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Summary:High-grade glioma (HGG) is a devastating disease with very poor prognosis. Maximal resection of HGG improves survival and maximal visualization of the tumor, if reliable, improves the resection. Fluorescence is widely used as guidance mechanism and has demonstrated potential in maximizing the extent of HGG resection. Our goal is to summarize the current techniques using fluorescence during the resection of HGG and demonstrate how its use increases gross total resection rates, overall survival (OS), and progression-free survival (PFS). However, further prospective, multicenter, randomized controlled trials are still in need to prove the advantage of fluorescence-guided surgery on patients' OS/PFS.
ISSN:2589-6113
2589-6121
DOI:10.4103/glioma.glioma_41_18