Mir-421 in plasma as a potential diagnostic biomarker for precancerous gastric lesions and early gastric cancer

MicroRNA (miR)-421 plays a key role in cancer progression. It has been reported that circulating miR-421may be a potential tumor marker for the diagnosis of several cancers. However, the role of miR-421 in plasma as a potential biomarker in the diagnosis of precancerous gastric lesions (Pre) and ear...

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Published in:PeerJ (San Francisco, CA) CA), 2019-06, Vol.7, p.e7002-e7002, Article e7002
Main Authors: Chen, Jianlin, Wu, Lihua, Sun, Yifan, Yin, Qi, Chen, Xianhua, Liang, Siqun, Meng, Qingyan, Long, Haihua, Li, Fangying, Luo, Changjun, Xiao, Xiaorong
Format: Article
Language:English
Subjects:
Analysis
Antigens
Biomarkers
Biopsy
Cancer
Cancer diagnosis
Cancer research
Cancer therapies
Carcinoembryonic antigen
Development and progression
Diagnosis
Early diagnosis
Evidence Based Medicine
Gastric cancer
Gastroenterology and Hepatology
Hospitals
Internal Medicine
Medical prognosis
Medical research
Medicine
MicroRNA
MicroRNA-421
MicroRNAs
miRNA
Novels
Pathology
Polymerase chain reaction
Precancerous lesions
Stomach cancer
Studies
Surgery and Surgical Specialties
Tumor markers
Tumors
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Summary:MicroRNA (miR)-421 plays a key role in cancer progression. It has been reported that circulating miR-421may be a potential tumor marker for the diagnosis of several cancers. However, the role of miR-421 in plasma as a potential biomarker in the diagnosis of precancerous gastric lesions (Pre) and early-stage gastric cancer (GC) remains poorly understood. In this study, we investigated miR-421 in plasma as a novel potential biomarker for the detection of precancerous gastric lesions and early-stage (GC). The miRNA content was determined by quantitative real-time polymerase chain reaction (qRT-PCR). MiR-421 content in all subjects was normalized by endogenous miRNA (miR-16). The diagnostic value of miR-421 for Pre and GC was assessed by comparing receiver operating characteristic (ROC) analysis with traditional tumor markers, including CEA, CA125, CA153, CA211 and CA50. The correlation between the expression of miR-421 and the pathological characteristics of Pre and GC was analyzed. Elevated expression of miR-421 in plasma can robustly distinguish the normal population from Pre and GC cases, especially in the early stages of gastric cancer cases (all  
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.7002