Schistosoma mansoni: effects of anesthetics and antimonial drugs on worm shift in the mouse

• Published in: Revista do Instituto de Medicina Tropical de São Paulo 1986-08, Vol.28 (4), p.267-270
• Main Authors: DE CUNHA-MELO, J. R, COELHO, P. M. Z
• Format: Article
• Language: English
• Subjects: Animals; Antimonial drugs; Antimony Sodium Gluconate - pharmacology; Biological and medical sciences; Diseases caused by trematodes; Experimental disease in mice; Female; Gluconates - pharmacology; Halothane - pharmacology; Helminthic diseases; Hypertension, Portal - etiology; Hypertension, Portal - parasitology; Hypertension, Portal - therapy; Infectious diseases; Liver - parasitology; Male; Manson schistosomiasis; Medical sciences; Mice; Mice, Inbred Strains; Parasitic diseases; Portal Vein - parasitology; Schistosoma mansoni - drug effects; Schistosomiases; Schistosomiasis mansoni - complications; Schistosomiasis mansoni - parasitology; Schistosomiasis mansoni - therapy; Thiopental - pharmacology; TROPICAL MEDICINE; Worm shift
• ISSN: 0036-4665; 1678-9946; 1678-9946; 0036-4665
• DOI: 10.1590/S0036-46651986000400010

Mice experimentally infected with Schistosoma mansoni were injected with sodium thiopental or sodium antimonyl gluconate (Triostib R), or submitted to halothane inhalation, with or without a previous injection of thiopental. Data obtained showed that halothane and thiopental induce worm shift to the liver (99 and 76%, respectively). Sodium gluconate and antimonium (Triostib R) shifted 52% of worms towards the liver. These results seem to indicate that the use of antimonium would be unnecessary, when surgical removal of schistosomules is carried out through the extracorporeal filtration technique, in patients with portal hypertension. Camundongos experimentalmente infectados com Schistosoma mansoni foram injetados com tiopental sódico ou antimonial (TriostibR), ou submetidos à inalação de halotano, com ou sem uma injeção prévia de tiopental. Os resultados mostraram que o halotano e o tiopental induzem, respectivamente, o deslocamento de 99 e 76% dos vermes para o fígado. Gluconato de sódio e antimonio (Triostib R) deslocou 52% de vermes. Estes resultados parecem indicar que o uso de antimonial seria desnecessário quando se faz a remoção cirúrgica de esquistossomos pela técnica de filtração extracorpórea em pacientes com hipertensão portal.