Echogenic Advantages of Ferrogels Filled with Magnetic Sub-Microparticles

Ultrasonic imaging of ferrogels (FGs) filled with magnetic nanoparticles does not reflect the inner structure of FGs due to the small size of particles. To determine whether larger particle size would improve the acoustic properties of FGs, biocompatible hydrogels filled with 100–400 nm iron oxide m...

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Bibliographic Details
Published in:Bioengineering (Basel) 2021-10, Vol.8 (10), p.140
Main Authors: Dinislamova, Olga, Bugayova, Antonina, Shklyar, Tatyana, Safronov, Alexander, Blyakhman, Felix
Format: Article
Language:English
Subjects:
Acoustic properties
Approximation
Biocompatibility
Bioengineering
bioengineering applications
Composite materials
ferrogels
Hydrogels
Iron oxides
Magnetic fields
magnetic particles
medical ultrasound
Microparticles
Nanoparticles
Particle size
Polyacrylamide
Polymerization
Polysaccharides
Regenerative medicine
Sedimentation & deposition
sonography
Tissue engineering
Ultrasonic imaging
Ultrasound
Viscosity
Water baths
Xanthan
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Summary:Ultrasonic imaging of ferrogels (FGs) filled with magnetic nanoparticles does not reflect the inner structure of FGs due to the small size of particles. To determine whether larger particle size would improve the acoustic properties of FGs, biocompatible hydrogels filled with 100–400 nm iron oxide magnetic sub-microparticles with weight fraction up to 23.3% were synthesized and studied. Polymeric networks of synthesized FGs were comprised of chemically cross-linked polyacrylamide with interpenetrating physical network of natural polysaccharide—Guar or Xanthan. Cylindrical samples approximately 10 mm in height and 13 mm in diameter were immersed in a water bath and examined using medical ultrasound (8.5 MHz). The acoustic properties of FGs were characterized by the intensity of reflected echo signal. It was found that the echogenicity of sub-microparticles provides visualization not only of the outer geometry of the gel sample but of its inner structure as well. In particular, the echogenicity of FGs interior depended on the concentration of magnetic particles in the FGs network. The ultrasound monitoring of the shape, dimensions, and inner structure of FGs in the applied external magnetic field is demonstrated. It is especially valuable for the application of FGs in tissue engineering and regenerative medicine.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering8100140