Revisiting Regulated Cell Death Responses in Viral Infections

The fate of a viral infection in the host begins with various types of cellular responses, such as abortive, productive, latent, and destructive infections. Apoptosis, necroptosis, and pyroptosis are the three major types of regulated cell death mechanisms that play critical roles in viral infection...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-06, Vol.23 (13), p.7023
Main Authors: Rex, Devasahayam Arokia Balaya, Keshava Prasad, Thottethodi Subrahmanya, Kandasamy, Richard K
Format: Article
Language:English
Subjects:
Apoptosis
Caspase
Cell death
Condensates
death receptors
Humans
Inflammation
Kinases
Membranes
Necroptosis
Pyroptosis
Pyroptosis - physiology
Regulated Cell Death
Review
signaling
viral infection
Viral infections
Virus Diseases
Viruses
Viruses - metabolism
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Summary:The fate of a viral infection in the host begins with various types of cellular responses, such as abortive, productive, latent, and destructive infections. Apoptosis, necroptosis, and pyroptosis are the three major types of regulated cell death mechanisms that play critical roles in viral infection response. Cell shrinkage, nuclear condensation, bleb formation, and retained membrane integrity are all signs of osmotic imbalance-driven cytoplasmic swelling and early membrane damage in necroptosis and pyroptosis. Caspase-driven apoptotic cell demise is considered in many circumstances as an anti-inflammatory, and some pathogens hijack the cell death signaling routes to initiate a targeted attack against the host. In this review, the selected mechanisms by which viruses interfere with cell death were discussed in-depth and were illustrated by compiling the general principles and cellular signaling mechanisms of virus-host-specific molecule interactions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23137023