The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment

Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria-primarily, the regulation of mitochondria-mediated apoptosis, Ca homeostasis, dynamics, energy production, and associated reactive oxygen...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-12, Vol.23 (1), p.460
Main Authors: Dabravolski, Siarhei A, Nikiforov, Nikita G, Zhuravlev, Alexander D, Orekhov, Nikolay A, Mikhaleva, Liudmila M, Orekhov, Alexander N
Format: Article
Language:English
Subjects:
Apoptosis
Calcium homeostasis
Calcium ions
Calcium signalling
Cancer therapies
Carcinogenesis
Carcinogenesis - metabolism
Carcinogens
Homeostasis
Humans
Kinases
Malignancy
Metastases
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Mitochondrial DNA
mitochondrial DNA mutation
mitochondrial dynamics
mitophagy
Mitophagy - drug effects
Molecular modelling
Mutation
Reactive Oxygen Species
Review
Thyroid cancer
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - metabolism
Tumors
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Summary:Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria-primarily, the regulation of mitochondria-mediated apoptosis, Ca homeostasis, dynamics, energy production, and associated reactive oxygen species generation. Recent studies have successfully confirmed the mitochondrial aetiology of thyroid carcinogenesis. In this review, we focus on the recent progress in understanding the molecular mechanisms of thyroid cancer relating to altered mitochondrial metabolism. We also discuss the repurposing of known drugs and the induction of mitochondria-mediated apoptosis as a new trend in the development of anti-TC therapy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23010460