Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats

• Published in: Clinical interventions in aging 2018-01, Vol.13, p.1555-1564
• Main Authors: Parvaneh, Maria, Karimi, Golgis, Jamaluddin, Rosita, Ng, Min Hwei, Zuriati, Ibrahim, Muhammad, Sani Ismaila
• Format: Article
• Language: English
• Subjects: Alendronate; Animals; Bone and Bones - metabolism; Bone density; Bone Density - drug effects; bone loss; bone mineral density; Bone Morphogenetic Protein 2 - metabolism; Bone morphogenetic proteins; Bone Remodeling - drug effects; Bone Resorption; Core Binding Factor Alpha 1 Subunit - metabolism; Female; Fractures; Fractures (Injuries); Gene expression; Health; Health aspects; Health sciences; Hormone replacement therapy; Humans; Immune system; Lactobacillus helveticus; Lactobacillus helveticus - metabolism; Lymphocytes; Menopause; Metabolism; Microbiota; Morbidity; Oophorectomy; Original Research; Osteoporosis; Osteoporosis, Postmenopausal - prevention & control; ovariectomized rats; Ovariectomy; Porosity; Postmenopausal women; Povidone; Preventive medicine; Probiotics; Rats; Rats, Sprague-Dawley; Skin; Up-Regulation; Womens health; Zoledronic acid
• ISSN: 1178-1998; 1176-9092; 1178-1998
• DOI: 10.2147/CIA.S169223

Osteoporosis is one of the major health concerns among the elderly population, especially in postmenopausal women. Many menopausal women over 50 years of age lose their bone density and suffer bone fractures. In addition, many mortality and morbidity cases among the elderly are related to hip fracture. This study aims to investigate the effect of ( ) on bone health status among ovariectomized (OVX) bone loss-induced rats. The rats were either OVX or sham OVX (sham), then were randomly assigned into three groups, G1: sham, G2: OVX and G3: OVX+ (1 mL of 10 -10 colony forming units). The supplementation was force-fed to the rats once a day for 16 weeks while control groups were force-fed with demineralized water. upregulated the expression of and , increased serum osteocalcin, bone volume/total volume and trabecular thickness, and decreased serum C-terminal telopeptide and total porosity percentage. It also altered bone microstructure, as a result increasing bone mineral density and bone strength. Our results indicate that attenuates bone remodeling and consequently improves bone health in OVX rats by increasing bone formation along with bone resorption reduction. This study suggests a potential therapeutic effect of (ATCC 27558) on postmenopausal osteoporosis.