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Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats
Osteoporosis is one of the major health concerns among the elderly population, especially in postmenopausal women. Many menopausal women over 50 years of age lose their bone density and suffer bone fractures. In addition, many mortality and morbidity cases among the elderly are related to hip fractu...
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| Published in: | Clinical interventions in aging 2018-01, Vol.13, p.1555-1564 |
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| creator | Parvaneh, Maria Karimi, Golgis Jamaluddin, Rosita Ng, Min Hwei Zuriati, Ibrahim Muhammad, Sani Ismaila |
| description | Osteoporosis is one of the major health concerns among the elderly population, especially in postmenopausal women. Many menopausal women over 50 years of age lose their bone density and suffer bone fractures. In addition, many mortality and morbidity cases among the elderly are related to hip fracture. This study aims to investigate the effect of
(
) on bone health status among ovariectomized (OVX) bone loss-induced rats.
The rats were either OVX or sham OVX (sham), then were randomly assigned into three groups, G1: sham, G2: OVX and G3: OVX+
(1 mL of 10
-10
colony forming units). The supplementation was force-fed to the rats once a day for 16 weeks while control groups were force-fed with demineralized water.
upregulated the expression of
and
, increased serum osteocalcin, bone volume/total volume and trabecular thickness, and decreased serum C-terminal telopeptide and total porosity percentage. It also altered bone microstructure, as a result increasing bone mineral density and bone strength.
Our results indicate that
attenuates bone remodeling and consequently improves bone health in OVX rats by increasing bone formation along with bone resorption reduction. This study suggests a potential therapeutic effect of
(ATCC 27558) on postmenopausal osteoporosis. |
| doi_str_mv | 10.2147/CIA.S169223 |
| format | article |
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(
) on bone health status among ovariectomized (OVX) bone loss-induced rats.
The rats were either OVX or sham OVX (sham), then were randomly assigned into three groups, G1: sham, G2: OVX and G3: OVX+
(1 mL of 10
-10
colony forming units). The supplementation was force-fed to the rats once a day for 16 weeks while control groups were force-fed with demineralized water.
upregulated the expression of
and
, increased serum osteocalcin, bone volume/total volume and trabecular thickness, and decreased serum C-terminal telopeptide and total porosity percentage. It also altered bone microstructure, as a result increasing bone mineral density and bone strength.
Our results indicate that
attenuates bone remodeling and consequently improves bone health in OVX rats by increasing bone formation along with bone resorption reduction. This study suggests a potential therapeutic effect of
(ATCC 27558) on postmenopausal osteoporosis.</description><identifier>ISSN: 1178-1998</identifier><identifier>ISSN: 1176-9092</identifier><identifier>EISSN: 1178-1998</identifier><identifier>DOI: 10.2147/CIA.S169223</identifier><identifier>PMID: 30214175</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Alendronate ; Animals ; Bone and Bones - metabolism ; Bone density ; Bone Density - drug effects ; bone loss ; bone mineral density ; Bone Morphogenetic Protein 2 - metabolism ; Bone morphogenetic proteins ; Bone Remodeling - drug effects ; Bone Resorption ; Core Binding Factor Alpha 1 Subunit - metabolism ; Female ; Fractures ; Fractures (Injuries) ; Gene expression ; Health ; Health aspects ; Health sciences ; Hormone replacement therapy ; Humans ; Immune system ; Lactobacillus helveticus ; Lactobacillus helveticus - metabolism ; Lymphocytes ; Menopause ; Metabolism ; Microbiota ; Morbidity ; Oophorectomy ; Original Research ; Osteoporosis ; Osteoporosis, Postmenopausal - prevention & control ; ovariectomized rats ; Ovariectomy ; Porosity ; Postmenopausal women ; Povidone ; Preventive medicine ; Probiotics ; Rats ; Rats, Sprague-Dawley ; Skin ; Up-Regulation ; Womens health ; Zoledronic acid</subject><ispartof>Clinical interventions in aging, 2018-01, Vol.13, p.1555-1564</ispartof><rights>COPYRIGHT 2018 Dove Medical Press Limited</rights><rights>2018. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Parvaneh et al. This work is published and licensed by Dove Medical Press Limited 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-5f75e0e0869b89edfcac7d5a05655276549f8fc7b4f2b682282e73775e2e56c03</citedby><orcidid>0000-0003-1229-0845 ; 0000-0002-5791-639X ; 0000-0001-6210-0443</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2224769482/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2224769482?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30214175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parvaneh, Maria</creatorcontrib><creatorcontrib>Karimi, Golgis</creatorcontrib><creatorcontrib>Jamaluddin, Rosita</creatorcontrib><creatorcontrib>Ng, Min Hwei</creatorcontrib><creatorcontrib>Zuriati, Ibrahim</creatorcontrib><creatorcontrib>Muhammad, Sani Ismaila</creatorcontrib><title>Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats</title><title>Clinical interventions in aging</title><addtitle>Clin Interv Aging</addtitle><description>Osteoporosis is one of the major health concerns among the elderly population, especially in postmenopausal women. Many menopausal women over 50 years of age lose their bone density and suffer bone fractures. In addition, many mortality and morbidity cases among the elderly are related to hip fracture. This study aims to investigate the effect of
(
) on bone health status among ovariectomized (OVX) bone loss-induced rats.
The rats were either OVX or sham OVX (sham), then were randomly assigned into three groups, G1: sham, G2: OVX and G3: OVX+
(1 mL of 10
-10
colony forming units). The supplementation was force-fed to the rats once a day for 16 weeks while control groups were force-fed with demineralized water.
upregulated the expression of
and
, increased serum osteocalcin, bone volume/total volume and trabecular thickness, and decreased serum C-terminal telopeptide and total porosity percentage. It also altered bone microstructure, as a result increasing bone mineral density and bone strength.
Our results indicate that
attenuates bone remodeling and consequently improves bone health in OVX rats by increasing bone formation along with bone resorption reduction. This study suggests a potential therapeutic effect of
(ATCC 27558) on postmenopausal osteoporosis.</description><subject>Alendronate</subject><subject>Animals</subject><subject>Bone and Bones - metabolism</subject><subject>Bone density</subject><subject>Bone Density - drug effects</subject><subject>bone loss</subject><subject>bone mineral density</subject><subject>Bone Morphogenetic Protein 2 - metabolism</subject><subject>Bone morphogenetic proteins</subject><subject>Bone Remodeling - drug effects</subject><subject>Bone Resorption</subject><subject>Core Binding Factor Alpha 1 Subunit - metabolism</subject><subject>Female</subject><subject>Fractures</subject><subject>Fractures (Injuries)</subject><subject>Gene expression</subject><subject>Health</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Immune system</subject><subject>Lactobacillus helveticus</subject><subject>Lactobacillus helveticus - metabolism</subject><subject>Lymphocytes</subject><subject>Menopause</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>Morbidity</subject><subject>Oophorectomy</subject><subject>Original Research</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - prevention & control</subject><subject>ovariectomized rats</subject><subject>Ovariectomy</subject><subject>Porosity</subject><subject>Postmenopausal women</subject><subject>Povidone</subject><subject>Preventive medicine</subject><subject>Probiotics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Skin</subject><subject>Up-Regulation</subject><subject>Womens health</subject><subject>Zoledronic acid</subject><issn>1178-1998</issn><issn>1176-9092</issn><issn>1178-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUl2LEzEUHURx19Un3yXgiyKtSWby9bJQix-FgqDrc8gkd7opM0lNZor9Cf5ro63rFiQPudx77sk9N6eqnhM8p6QRb5erxfwr4YrS-kF1SYiQM6KUfHgvvqie5LzFmHHB6OPqosalkwh2Wf1cGzvG1ljf91NGt9DvYfS2hK8WN8slooIx-RpNuwSbqTcjZPRlCj8oMsGhd8PuGAzRnYptDIAGHyCZHjkI2Y8H5AOKe5M8lKeGw8wHN1lwR2wfc0bJjPlp9agzfYZnp_uq-vbh_c3y02z9-eNquVjPLGvoOGOdYIABS65aqcB11ljhmCnaGKOCs0Z1srOibTrackmppCBqUZooMG5xfVWtjrwumq3eJT-YdNDReP0nEdNGm1RW0IMmhPGGSA7CuKZTWLHGCIpr22LhVM0K1_WRaze1AzgLYSy6z0jPK8Hf6k3ca04oEVwUgpcnghS_T5BHvY1TCkW_ppQ2gqtG0n-ojSlT-dDFQmYHn61eMMGIkliogpr_B1WOg8HbsuvOl_xZw5tjg03lExJ0d4MTrH9bSxdr6ZO1CvrFfa132L9eqn8BsSHHvQ</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Parvaneh, Maria</creator><creator>Karimi, Golgis</creator><creator>Jamaluddin, Rosita</creator><creator>Ng, Min Hwei</creator><creator>Zuriati, Ibrahim</creator><creator>Muhammad, Sani Ismaila</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1229-0845</orcidid><orcidid>https://orcid.org/0000-0002-5791-639X</orcidid><orcidid>https://orcid.org/0000-0001-6210-0443</orcidid></search><sort><creationdate>20180101</creationdate><title>Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats</title><author>Parvaneh, Maria ; Karimi, Golgis ; Jamaluddin, Rosita ; Ng, Min Hwei ; Zuriati, Ibrahim ; Muhammad, Sani Ismaila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-5f75e0e0869b89edfcac7d5a05655276549f8fc7b4f2b682282e73775e2e56c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alendronate</topic><topic>Animals</topic><topic>Bone and Bones - metabolism</topic><topic>Bone density</topic><topic>Bone Density - drug effects</topic><topic>bone loss</topic><topic>bone mineral density</topic><topic>Bone Morphogenetic Protein 2 - metabolism</topic><topic>Bone morphogenetic proteins</topic><topic>Bone Remodeling - drug effects</topic><topic>Bone Resorption</topic><topic>Core Binding Factor Alpha 1 Subunit - metabolism</topic><topic>Female</topic><topic>Fractures</topic><topic>Fractures (Injuries)</topic><topic>Gene expression</topic><topic>Health</topic><topic>Health aspects</topic><topic>Health sciences</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Immune system</topic><topic>Lactobacillus helveticus</topic><topic>Lactobacillus helveticus - metabolism</topic><topic>Lymphocytes</topic><topic>Menopause</topic><topic>Metabolism</topic><topic>Microbiota</topic><topic>Morbidity</topic><topic>Oophorectomy</topic><topic>Original Research</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - prevention & control</topic><topic>ovariectomized rats</topic><topic>Ovariectomy</topic><topic>Porosity</topic><topic>Postmenopausal women</topic><topic>Povidone</topic><topic>Preventive medicine</topic><topic>Probiotics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Skin</topic><topic>Up-Regulation</topic><topic>Womens health</topic><topic>Zoledronic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parvaneh, Maria</creatorcontrib><creatorcontrib>Karimi, Golgis</creatorcontrib><creatorcontrib>Jamaluddin, Rosita</creatorcontrib><creatorcontrib>Ng, Min Hwei</creatorcontrib><creatorcontrib>Zuriati, Ibrahim</creatorcontrib><creatorcontrib>Muhammad, Sani Ismaila</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Clinical interventions in aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parvaneh, Maria</au><au>Karimi, Golgis</au><au>Jamaluddin, Rosita</au><au>Ng, Min Hwei</au><au>Zuriati, Ibrahim</au><au>Muhammad, Sani Ismaila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats</atitle><jtitle>Clinical interventions in aging</jtitle><addtitle>Clin Interv Aging</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>13</volume><spage>1555</spage><epage>1564</epage><pages>1555-1564</pages><issn>1178-1998</issn><issn>1176-9092</issn><eissn>1178-1998</eissn><abstract>Osteoporosis is one of the major health concerns among the elderly population, especially in postmenopausal women. Many menopausal women over 50 years of age lose their bone density and suffer bone fractures. In addition, many mortality and morbidity cases among the elderly are related to hip fracture. This study aims to investigate the effect of
(
) on bone health status among ovariectomized (OVX) bone loss-induced rats.
The rats were either OVX or sham OVX (sham), then were randomly assigned into three groups, G1: sham, G2: OVX and G3: OVX+
(1 mL of 10
-10
colony forming units). The supplementation was force-fed to the rats once a day for 16 weeks while control groups were force-fed with demineralized water.
upregulated the expression of
and
, increased serum osteocalcin, bone volume/total volume and trabecular thickness, and decreased serum C-terminal telopeptide and total porosity percentage. It also altered bone microstructure, as a result increasing bone mineral density and bone strength.
Our results indicate that
attenuates bone remodeling and consequently improves bone health in OVX rats by increasing bone formation along with bone resorption reduction. This study suggests a potential therapeutic effect of
(ATCC 27558) on postmenopausal osteoporosis.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>30214175</pmid><doi>10.2147/CIA.S169223</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1229-0845</orcidid><orcidid>https://orcid.org/0000-0002-5791-639X</orcidid><orcidid>https://orcid.org/0000-0001-6210-0443</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1178-1998 |
| ispartof | Clinical interventions in aging, 2018-01, Vol.13, p.1555-1564 |
| issn | 1178-1998 1176-9092 1178-1998 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_11564186e7ad4f90954a7203cb07d935 |
| source | Open Access: PubMed Central; Publicly Available Content Database; Taylor & Francis Open Access Journals |
| subjects | Alendronate Animals Bone and Bones - metabolism Bone density Bone Density - drug effects bone loss bone mineral density Bone Morphogenetic Protein 2 - metabolism Bone morphogenetic proteins Bone Remodeling - drug effects Bone Resorption Core Binding Factor Alpha 1 Subunit - metabolism Female Fractures Fractures (Injuries) Gene expression Health Health aspects Health sciences Hormone replacement therapy Humans Immune system Lactobacillus helveticus Lactobacillus helveticus - metabolism Lymphocytes Menopause Metabolism Microbiota Morbidity Oophorectomy Original Research Osteoporosis Osteoporosis, Postmenopausal - prevention & control ovariectomized rats Ovariectomy Porosity Postmenopausal women Povidone Preventive medicine Probiotics Rats Rats, Sprague-Dawley Skin Up-Regulation Womens health Zoledronic acid |
| title | Lactobacillus helveticus (ATCC 27558) upregulates Runx2 and Bmp2 and modulates bone mineral density in ovariectomy-induced bone loss rats |
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