Porcine rotavirus B as primary causative agent of diarrhea outbreaks in newborn piglets

Rotavirus (RV) is considered a major cause of acute viral gastroenteritis in young animals. RV is classified into nine species, five of which have been identified in pigs. Most studies worldwide have highlighted diarrhoea outbreaks caused by RVA, which is considered the most important RV species. In...

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Bibliographic Details
Published in:Scientific reports 2020-12, Vol.10 (1), p.22002-22002, Article 22002
Main Authors: Miyabe, Flavia Megumi, Dall Agnol, Alais Maria, Leme, Raquel Arruda, Oliveira, Thalita Evani Silva, Headley, Selwyn Arlington, Fernandes, Thiago, de Oliveira, Admilton Gonçalves, Alfieri, Alice Fernandes, Alfieri, Amauri Alcindo
Format: Article
Language:English
Subjects:
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Animals
Animals, Newborn
Base Sequence
Diarrhea
Diarrhea - epidemiology
Diarrhea - pathology
Diarrhea - veterinary
Diarrhea - virology
Differential diagnosis
Disease Outbreaks - veterinary
Gastroenteritis
Genotypes
Hogs
Humanities and Social Sciences
multidisciplinary
Outbreaks
Phylogeny
Rotavirus
Rotavirus - genetics
Rotavirus - isolation & purification
Rotavirus - physiology
Rotavirus - ultrastructure
Rotavirus Infections - epidemiology
Rotavirus Infections - pathology
Rotavirus Infections - veterinary
Rotavirus Infections - virology
Science
Science (multidisciplinary)
Swine
Swine Diseases - epidemiology
Swine Diseases - pathology
Swine Diseases - virology
Viral Proteins - metabolism
Viruses
VP7 gene
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Summary:Rotavirus (RV) is considered a major cause of acute viral gastroenteritis in young animals. RV is classified into nine species, five of which have been identified in pigs. Most studies worldwide have highlighted diarrhoea outbreaks caused by RVA, which is considered the most important RV species. In the present study, we described the detection and characterization of porcine RVB as a primary causative agent of diarrhoea outbreaks in pig herds in Brazil. The study showed a high frequency (64/90; 71.1%) of RVB diagnosis in newborn piglets associated with marked histopathological lesions in the small intestines. Phylogenetic analysis of the VP7 gene of wild-type RVB strains revealed a high diversity of G genotypes circulating in one geographic region of Brazil. Our findings suggest that RVB may be considered an important primary enteric pathogen in piglets and should be included in the routine differential diagnosis of enteric diseases in piglets.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-78797-y