Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection

The present study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 3 (TLR3) gene in patients infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitat...

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Published in:Revista da Sociedade Brasileira de Medicina Tropical 2015-04, Vol.48 (2), p.136-142
Main Authors: Sá, Keyla Santos Guedes de, Pires-Neto, Orlando de Souza, Santana, Barbara Brasil, Gomes, Samara Tatielle Monteiro, Amoras, Ednelza da Silva Graça, Conde, Simone Regina da Silva, Demachki, Sâmia, Azevedo, Vânia Nakauth, Machado, Luiz Fernando Almeida, Martins-Feitosa, Rosimar Neris, Ishak, Marluísa de Oliveira Guimarães, Ishak, Ricardo, Vallinoto, Antonio Carlos Rosário
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alanine Transaminase - blood
Alleles
Aspartate Aminotransferases - blood
Disease Progression
Female
gamma-Glutamyltransferase - blood
Genotype
Haplotypes
HBV
HCV
Hepatitis B, Chronic - genetics
Hepatitis C, Chronic - genetics
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide - genetics
Risk Factors
rs3775291
rs5743305
TLR3
Toll-Like Receptor 3 - genetics
TROPICAL MEDICINE
Young Adult
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Summary:The present study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 3 (TLR3) gene in patients infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT). A healthy control group was investigated and consisted of 299 HCV- and HBV-seronegative individuals. No significant differences in allele, genotype and haplotype frequencies were observed between the investigated groups, and no association was observed between the polymorphisms and histopathological results. Nevertheless, genotypes TA/AA (rs5743305) and GG (rs3775291) appear to be associated with higher levels of ALT (p
ISSN:0037-8682
1678-9849
1678-9849
0037-8682
DOI:10.1590/0037-8682-0008-2015