Electrochemical oxidation of allylic C H bond for α, β-unsaturated ketones without peroxide

α,β-Unsaturated ketone is one of the important building blocks of the plenty of alkaloids, spices and pharmaceutical agents. Herein, we describe a peroxide-free electrochemical strategy to realize site-selective allylic C − H oxidation for the synthesis of α,β-unsaturated ketones. This electrochemic...

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Bibliographic Details
Published in:Journal of Saudi Chemical Society 2023-07, Vol.27 (4), p.101673, Article 101673
Main Authors: Zang, Zhong-Lin, Wang, Qi, Dong, Zhi-Chao, Huang, Sheng-Yao, Wu, Hao-Zeng, Zhou, Cheng-He, Cai, Gui-Xin
Format: Article
Language:English
Subjects:
Allylic C–H oxidation
Electrochemistry
Peroxide-free
Sustainable chemistry
α,β-Unsaturated ketones
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Summary:α,β-Unsaturated ketone is one of the important building blocks of the plenty of alkaloids, spices and pharmaceutical agents. Herein, we describe a peroxide-free electrochemical strategy to realize site-selective allylic C − H oxidation for the synthesis of α,β-unsaturated ketones. This electrochemically driven oxidation exhibits a broad substrate scope. Mechanistic investigations of this reaction uncovered HOAc and H2O as the oxygen source to achieve peroxide-free electrochemical allylic C − H oxidation.
ISSN:1319-6103
DOI:10.1016/j.jscs.2023.101673