New Insights into the Immune Molecular Regulation of the Pathogenesis of Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome is an inflammatory disease characterized by dysfunction of pulmonary epithelial and capillary endothelial cells, infiltration of alveolar macrophages and neutrophils, cell apoptosis, necroptosis, NETosis, and fibrosis. Inflammatory responses have key effects on eve...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-02, Vol.19 (2), p.588
Main Authors: Yang, Chin-Yao, Chen, Chien-Sheng, Yiang, Giou-Teng, Cheng, Yeung-Leung, Yong, Su-Boon, Wu, Meng-Yu, Li, Chia-Jung
Format: Article
Language:English
Subjects:
acute respiratory distress syndrome
Alveoli
Apoptosis
Cascades
Disease control
Endothelial cells
Fibrosis
Immune system
Inflammation
Leukocytes (neutrophilic)
Macrophages
Molecular biology
Necroptosis
NETosis
Pathogenesis
Permeability
Respiratory distress syndrome
Respiratory therapy
Review
sepsis
Smoke inhalation
Therapeutic applications
vascular permeability
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Summary:Acute respiratory distress syndrome is an inflammatory disease characterized by dysfunction of pulmonary epithelial and capillary endothelial cells, infiltration of alveolar macrophages and neutrophils, cell apoptosis, necroptosis, NETosis, and fibrosis. Inflammatory responses have key effects on every phase of acute respiratory distress syndrome. The severe inflammatory cascades impaired the regulation of vascular endothelial barrier and vascular permeability. Therefore, understanding the relationship between the molecular regulation of immune cells and the pulmonary microenvironment is critical for disease management. This article reviews the current clinical and basic research on the pathogenesis of acute respiratory distress syndrome, including information on the microenvironment, vascular endothelial barrier and immune mechanisms, to offer a strong foundation for developing therapeutic interventions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19020588