Chemistry and bioactivities of natural steroidal alkaloids

Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule. They have demonstrated a wide range of biological activities, and some of them have even been developed as therapeutic drugs, such as abiraterone ac...

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Bibliographic Details
Published in:Natural products and bioprospecting 2022-12, Vol.12 (1), p.23-23, Article 23
Main Authors: Xiang, Mei-Ling, Hu, Bin-Yuan, Qi, Zi-Heng, Wang, Xiao-Na, Xie, Tian-Zhen, Wang, Zhao-Jie, Ma, Dan-Yu, Zeng, Qi, Luo, Xiao-Dong
Format: Article
Language:English
Subjects:
Acetic acid
Alkaloids
Angina pectoris
Apocynaceae
Bioactivities
Biomedical and Life Sciences
Bioorganic Chemistry
Biosynthesis
Cardiovascular disease
Chemistry
FDA approval
Food Science
Life Sciences
Liliaceae
Medicinal Chemistry
Metastasis
Natural products
Nitrogen
Pharmaceutical sciences
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Poisons
Prostate cancer
R&D
Research & development
Review
Solanaceae
Steroidal alkaloids
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Summary:Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule. They have demonstrated a wide range of biological activities, and some of them have even been developed as therapeutic drugs, such as abiraterone acetate (Zytiga ® ), a blockbuster drug, which has been used for the treatment of prostate cancer. Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities, which are attractive for natural product chemistry and medicinal chemistry communities. This review comprehensively covers the structural classification, isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021, with 363 references being cited.
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-022-00345-0