Genetic counseling prior to assisted reproductive technology

Background Reproductive medicine deals with fertility and is closely related to heredity. In reproductive medicine, it is necessary to provide genetic information for the patients prior to assisted reproductive technology (ART). Japan Society for Reproductive Medicine (JSRM) requires doctors involve...

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Bibliographic Details
Published in:Reproductive medicine and biology 2021-04, Vol.20 (2), p.133-143
Main Authors: Katagiri, Yukiko, Tamaki, Yuko
Format: Article
Language:English
Subjects:
Babies
Birth defects
Children
chromosomal abnormalities
Chromosome aberrations
Congenital defects
Congenital diseases
Embryos
Endometrium
Epigenetic inheritance
Epigenetics
Fertility
Genetic counseling
Genetic disorders
Genotype & phenotype
Hypertension
Infertility
intracytoplasmic sperm injection
Medical care
Medical genetics
Medical societies
Medicine
Mini Review
Mini Reviews
Newborn babies
Placenta
Preeclampsia
Pregnancy
Pregnancy complications
Quality management
Reproductive health
Reproductive technologies
Reproductive technology
X chromosomes
Y chromosome microdeletions
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Summary:Background Reproductive medicine deals with fertility and is closely related to heredity. In reproductive medicine, it is necessary to provide genetic information for the patients prior to assisted reproductive technology (ART). Japan Society for Reproductive Medicine (JSRM) requires doctors involved in reproductive medicine to have standard knowledge of reproductive genetics and knowledge of reproductive medicine, which is covered in their publication, “required knowledge of reproductive medicine.” Methods With the aim of providing straightforward explanations to patients in the clinical situation at pre‐ART counseling, we provide the following five topics, such as (a) risk of birth defects in children born with ART, (b) chromosomal abnormalities, (c) Y chromosome microdeletions (YCMs), (d) possible chromosomal abnormal pregnancy in oligospermatozoa requiring ICSI (intracytoplasmic sperm injection), and (e) epigenetic alterations. Main findings The frequency of chromosome abnormalities in infertile patients is 0.595%‐0.64%. YCMs are observed in 2%‐10% of severe oligospermic men. High incidence of spermatozoa with chromosomal abnormalities has been reported in advanced oligospermia and asthenozoospermia that require ICSI. Some epigenetic alterations were reported in the children born with ART. Conclusion Certain genetic knowledge is important for professionals involved in reproductive medicine, even if they are not genetic experts.
ISSN:1445-5781
1447-0578
DOI:10.1002/rmb2.12361