The association between cognition and gait disturbance in central nervous system demyelinating disorder with mild disability

Gait disturbance in central nervous system (CNS) demyelinating disorders, including multiple sclerosis (MS) and neuromyelitis optica (NMO) is one of the most troublesome problems that has a direct impact on the quality of life. However, the associations between gait disturbance and other clinical va...

Full description

Saved in:
Bibliographic Details
Published in:BMC neurology 2023-04, Vol.23 (1), p.177-177, Article 177
Main Authors: Chang, Min Cheol, Lee, Byung Joo, Yang, Dongseok, Kim, Chung Reen, Park, Donghwi, Kim, Sunyoung
Format: Article
Language:English
Subjects:
Body mass index
Care and treatment
Central Nervous System
Central Nervous System Diseases - complications
Chronic illnesses
Cognition
Cognition & reasoning
Cognitive ability
Cognitive appraisal
Cognitive function
Complications and side effects
Demyelinating diseases
Demyelination
Disease
Fatigue
Gait
Gait Analysis
Gait disorders
Genetic aspects
Hand Strength
Health aspects
Humans
Medical research
Methods
Movement disorders
Multiple sclerosis
Multiple Sclerosis - psychology
Musculoskeletal system
Nervous system
Neuromyelitis
Neuromyelitis optica
Neuromyelitis Optica - diagnosis
Patients
Prevention
Quality of Life
Questionnaires
Regression analysis
Risk factors
Skeletal muscle
Statistical analysis
Walkways
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gait disturbance in central nervous system (CNS) demyelinating disorders, including multiple sclerosis (MS) and neuromyelitis optica (NMO) is one of the most troublesome problems that has a direct impact on the quality of life. However, the associations between gait disturbance and other clinical variables of these two diseases have not been fully elucidated. This study aimed to evaluate gait disturbance using a computerized gait analysis system and its association with various clinical variables in patients with MS and NMO. A total of 33 patients (14 with MS and 19 with NMO) with minor disabilities, who were able to walk independently and had passed their acute phase, were enrolled in the study. Gait analysis were performed using a computer-based instrumented walkway system. (Walk-way MG-1000, Anima, Japan) Clinical variables, such as disease duration, medication, body mass index (BMI), hand grip power, and muscle mass were recorded. The Montreal Cognitive Assessment (MOCA), Beck Depression Inventory score-II (BDI), and fatigue scale were measured using the Functional Assessment of Chronic Illness Therapy-fatigue scale (FACIT-fatigue) scale. A trained neurologist scored the Expanded Disability Status Scale (EDSS). Gait speed was the single parameter that showed a significant positive correlation with MOCA (p 
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-023-03210-w