Vitamin D Supplementation in Patients with Juvenile Idiopathic Arthritis

Vitamin D has been implicated in the pathogenesis of skeletal disorders and various autoimmune disorders. Vitamin D can be consumed from the diet or synthesized in the skin upon ultraviolet exposure and hydroxylation in the liver and kidneys. In its bioactive form, vitamin D exerts a potent immunomo...

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Bibliographic Details
Published in:Nutrients 2022-04, Vol.14 (8), p.1538
Main Authors: Wu, Chao-Yi, Yang, Huang-Yu, Luo, Shue-Fen, Huang, Jing-Long, Lai, Jenn-Haung
Format: Article
Language:English
Subjects:
Adaptive systems
Arthritis
Arthritis, Juvenile - drug therapy
Autoimmune diseases
Bone Density
Bone Diseases, Metabolic
Bone growth
bone metabolism
Bone turnover
Bones
Calciferol
Child
Cytokines
Deformation effects
Dendritic cells
Dietary Supplements
Disease
Homeostasis
Humans
Hydroxylation
immune regulation
Immune system
Immunomodulation
Inflammation
Joint diseases
juvenile idiopathic arthritis
Kidneys
Metabolism
Metabolites
Mineralization
Patients
Review
supplementation
Synovium
Systems analysis
Tumor necrosis factor-TNF
Vitamin D
Vitamin D - metabolism
Vitamin D Deficiency - complications
Vitamin D Deficiency - drug therapy
Vitamin deficiency
Vitamins
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Summary:Vitamin D has been implicated in the pathogenesis of skeletal disorders and various autoimmune disorders. Vitamin D can be consumed from the diet or synthesized in the skin upon ultraviolet exposure and hydroxylation in the liver and kidneys. In its bioactive form, vitamin D exerts a potent immunomodulatory effect and is important for bone health. Juvenile idiopathic arthritis (JIA) is a collection of inflammatory joint diseases in children that share the manifestation of inflamed synovium, which can result in growth arrest, articular deformity, bone density loss, and disability. To evaluate the potential effect of vitamin D on JIA disease manifestations and outcomes, we review the role of vitamin D in bone metabolism, discuss the mechanism of vitamin D in modulating the innate and adaptive immune systems, evaluate the clinical significance of vitamin D in patients with JIA, and summarize the supplementation studies.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14081538