Simultaneous occurrence of axonal Guillain-Barré syndrome in two siblings following dengue infection

Guillain-Barré syndrome (GBS) is an infrequent neurological complication of dengue viral infection. It is broadly divided into either acute inflammatory demyelinating variety or an axonal variety (acute motor axonal and acute sensory and motor axonal variants). Axonal variants are distinctly infrequ...

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Bibliographic Details
Published in:Annals of the Indian Academy of Neurology 2018-10, Vol.21 (4), p.315-317
Main Authors: Pandey, Shweta, Garg, Ravindra, Malhotra, Hardeep, Kumar, Neeraj, Uniyal, Ravi
Format: Article
Language:English
Subjects:
Antigens
Autoimmune
Case Report
Demyelination
Dengue fever
dengue virus
Electrolytes
Enzymes
Fever
genetic susceptibility
Guillain-Barre syndrome
Guillain–Barré syndrome
Hepatitis
Immunoglobulin M
Infections
Inflammation
Nerve conduction
Nervous system
Pathogenesis
Patients
Serology
Siblings
Urine
Viral infections
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Summary:Guillain-Barré syndrome (GBS) is an infrequent neurological complication of dengue viral infection. It is broadly divided into either acute inflammatory demyelinating variety or an axonal variety (acute motor axonal and acute sensory and motor axonal variants). Axonal variants are distinctly infrequent. Two brothers (18 years and 15 years) were hospitalized on the same day with complaints of acute symmetric upper- and lower-limb weakness of 7 days' duration. They did not have overt manifestations of dengue fever which preceded the neurological presentation. They had flaccid areflexic pure motor quadriparesis. Dengue IgM serology was positive in both. Nerve conduction study showed predominant axonopathic changes in both the patients. Both the patients showed significant improvement with conservative treatment during hospital stay of 7 days. This is unusual report of dengue-associated axonal GBS in two brothers. Whether simultaneous occurrence of GBS in two siblings is a coincidence or genetically determined is still a question.
ISSN:0972-2327
1998-3549
DOI:10.4103/aian.AIAN_454_17