A Data-Driven Approach to Construct a Molecular Map of Trypanosoma cruzi to Identify Drugs and Vaccine Targets

Chagas disease (CD) is endemic in large parts of Central and South America, as well as in Texas and the southern regions of the United States. Successful parasites, such as the causative agent of CD, have adapted to specific hosts during their phylogenesis. In this work, we have assembled an interac...

Full description

Saved in:
Bibliographic Details
Published in:Vaccines (Basel) 2023-01, Vol.11 (2), p.267
Main Authors: Nath, Swarsat Kaushik, Pankajakshan, Preeti, Sharma, Trapti, Kumari, Priya, Shinde, Sweety, Garg, Nikita, Mathur, Kartavya, Arambam, Nevidita, Harjani, Divyank, Raj, Manpriya, Kwatra, Garwit, Venkatesh, Sayantan, Choudhoury, Alakto, Bano, Saima, Tayal, Prashansa, Sharan, Mahek, Arora, Ruchika, Strych, Ulrich, Hotez, Peter J, Bottazzi, Maria Elena, Rawal, Kamal
Format: Article
Language:English
Subjects:
Benznidazole
Chagas disease
Data mining
Disease
DNA helicase
Docking
Drugs
Extracellular matrix
Gene expression
gene ontology
Genomes
Infections
Keywords
Medical research
Metabolism
Nifurtimox
Ontology
Parasites
Pathogens
pathways
Phenotypes
Proteins
Protozoa
system biology
Target recognition
trans-Sialidase
Trypanosoma cruzi
vaccine targets
Vaccines
Vector-borne diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chagas disease (CD) is endemic in large parts of Central and South America, as well as in Texas and the southern regions of the United States. Successful parasites, such as the causative agent of CD, have adapted to specific hosts during their phylogenesis. In this work, we have assembled an interactive network of the complex relations that occur between molecules within . An expert curation strategy was combined with a text-mining approach to screen 10,234 full-length research articles and over 200,000 abstracts relevant to . We obtained a scale-free network consisting of 1055 nodes and 874 edges, and composed of 838 proteins, 43 genes, 20 complexes, 9 RNAs, 36 simple molecules, 81 phenotypes, and 37 known pharmaceuticals. Further, we deployed an automated docking pipeline to conduct large-scale docking studies involving several thousand drugs and potential targets to identify network-based binding propensities. These experiments have revealed that the existing FDA-approved drugs benznidazole (Bz) and nifurtimox (Nf) show comparatively high binding energies to the network proteins (e.g., PIF1 helicase-like protein, trans-sialidase), when compared with control datasets consisting of proteins from other pathogens. We envisage this work to be of value to those interested in finding new vaccines for CD, as well as drugs against the parasite.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines11020267