Differential effects of lead and zinc on inhibitory avoidance learning in mice

We studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2001-01, Vol.34 (1), p.117-120
Main Authors: de Oliveira, F S, Viana, M R, Antoniolli, A R, Marchioro, M
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning - drug effects
BIOLOGY
Female
inhibitory avoidance
lead
Lead - toxicity
Male
MEDICINE, RESEARCH & EXPERIMENTAL
memory
Mice
Pregnancy
Prenatal Exposure Delayed Effects
Retention (Psychology) - drug effects
zinc
Zinc - toxicity
Zinc Acetate - toxicity
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Summary:We studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal intoxication with Pb2+ did not change the step-through latency values recorded during the 4 weeks of the test (ANOVA, P>0.05). In contrast, mice intoxicated during the prenatal period showed significantly reduced latency values when compared to the control group (day 1: q = 4.62, P
ISSN:0100-879X
1414-431X
0100-879X
1414-431X
DOI:10.1590/S0100-879X2001000100014