Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases

Mitochondria are complex organelles that orchestrate several functions in the cell. The primary function recognized is energy production; however, other functions involve the communication with the rest of the cell through reactive oxygen species (ROS), calcium influx, mitochondrial DNA (mtDNA), ade...

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Published in:Biomolecules (Basel, Switzerland) Switzerland), 2021-08, Vol.11 (9), p.1259
Main Authors: Jiménez-Uribe, Alexis Paulina, Hernández-Cruz, Estefani Yaquelin, Ramírez-Magaña, Karla Jaqueline, Pedraza-Chaverri, José
Format: Article
Language:English
Subjects:
Adenosine
Adenosine triphosphate
Animals
Apoptosis
Bioenergetics
Biomarkers - metabolism
Calcium (mitochondrial)
Calcium influx
Cancer
Cell interactions
Citric Acid Cycle
Cytochrome c
Cytosol
Dehydrogenases
Diabetes
Electron transport
Enzymes
Epigenetics
Fatty acids
Fibroblasts
Gene expression
Humans
Hypoxia
Kidney diseases
Kidney Diseases - metabolism
Kinases
Lipids
Metabolic pathways
Metabolism
Metabolites
Metabolome
Mitochondria
Mitochondrial DNA
Models, Biological
Organelles
Oxidation
Oxidative phosphorylation
Phosphorylation
Proteins
Reactive oxygen species
Renal function
Review
TCA cycle metabolites
Tricarboxylic acid cycle
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cited_by cdi_FETCH-LOGICAL-c544t-a36d16aed9eea3d58454386a7a3088d4a31bc4e2669e7b1f6ab1e55ba1478ab53
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container_title Biomolecules (Basel, Switzerland)
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creator Jiménez-Uribe, Alexis Paulina
Hernández-Cruz, Estefani Yaquelin
Ramírez-Magaña, Karla Jaqueline
Pedraza-Chaverri, José
description Mitochondria are complex organelles that orchestrate several functions in the cell. The primary function recognized is energy production; however, other functions involve the communication with the rest of the cell through reactive oxygen species (ROS), calcium influx, mitochondrial DNA (mtDNA), adenosine triphosphate (ATP) levels, cytochrome c release, and also through tricarboxylic acid (TCA) metabolites. Kidney function highly depends on mitochondria; hence mitochondrial dysfunction is associated with kidney diseases. In addition to oxidative phosphorylation impairment, other mitochondrial abnormalities have been described in kidney diseases, such as induction of mitophagy, intrinsic pathway of apoptosis, and releasing molecules to communicate to the rest of the cell. The TCA cycle is a metabolic pathway whose primary function is to generate electrons to feed the electron transport system (ETS) to drives energy production. However, TCA cycle metabolites can also release from mitochondria or produced in the cytosol to exert different functions and modify cell behavior. Here we review the involvement of some of the functions of TCA metabolites in kidney diseases.
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subjects Adenosine
Adenosine triphosphate
Animals
Apoptosis
Bioenergetics
Biomarkers - metabolism
Calcium (mitochondrial)
Calcium influx
Cancer
Cell interactions
Citric Acid Cycle
Cytochrome c
Cytosol
Dehydrogenases
Diabetes
Electron transport
Enzymes
Epigenetics
Fatty acids
Fibroblasts
Gene expression
Humans
Hypoxia
Kidney diseases
Kidney Diseases - metabolism
Kinases
Lipids
Metabolic pathways
Metabolism
Metabolites
Metabolome
Mitochondria
Mitochondrial DNA
Models, Biological
Organelles
Oxidation
Oxidative phosphorylation
Phosphorylation
Proteins
Reactive oxygen species
Renal function
Review
TCA cycle metabolites
Tricarboxylic acid cycle
title Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases
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