A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease

Background Patients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are typically managed with non-invasive ventilation (NIV). The impact of low-flow extracorporeal carbon dioxide removal (ECCO 2 R) on outcome in these pati...

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Bibliographic Details
Published in:Annals of intensive care 2022-04, Vol.12 (1), p.36-10, Article 36
Main Authors: Barrett, Nicholas A., Hart, Nicholas, Daly, Kathleen J. R., Marotti, Martina, Kostakou, Eirini, Carlin, Chris, Lua, Stephanie, Singh, Suveer, Bentley, Andrew, Douiri, Abdel, Camporota, Luigi
Format: Article
Language:English
Subjects:
Acute exacerbations of chronic obstructive pulmonary disease
AECOPD
Anesthesiology
Carbon dioxide removal
Chronic obstructive pulmonary disease
Critical Care Medicine
Dyspnea
ECCO2R
Emergency Medicine
Extracorporeal CO2 removal
Intensive
Intensive care
Medicine
Medicine & Public Health
NCT
NCT02086084
NIV
Non-invasive ventilation
Oxygen therapy
Respiratory failure
Ventilation
Ventilators
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Summary:Background Patients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are typically managed with non-invasive ventilation (NIV). The impact of low-flow extracorporeal carbon dioxide removal (ECCO 2 R) on outcome in these patients has not been explored in randomised trials. Methods Open-label randomised trial comparing NIV (NIV arm) with ECCO 2 R (ECCO 2 R arm) in patients with AECOPD at high risk of NIV failure (pH 
ISSN:2110-5820
2110-5820
DOI:10.1186/s13613-022-01006-8